Antifungal Activity and Phytochemical Analysis of Aqueous Extracts of Ricinus communis and Punica granatum
Journal Title: Journal of Pharmacy Research - Year 2011, Vol 4, Issue 1
Abstract
In the present investigation, the aqueous leaf and pericarp extracts of castor oil plant (Ricinus communis) and pomegranate (Punica granatum) were evaluated for antifungal activity against Candida species and subsequently phytochemical analysis of the crude extracts was carried out to determine the active phytochemical constituents responsible for antifungal activity. It was observed that aqueous leaf extract of R. communis was effective in inhibiting Candida albicans, C. glabrata and C. tropicalis with zone of inhibition ranging between 17mm and 32 mm followed by aqueous pericarp extract of Punica granatum which inhibited two species of Candida namely C. glabrata and C. albicans with zone of growth inhibition between 24mm and 37mm. All the Candida species, except C. tropicalis were resistant to the positive control, ketoconazole. Phytochemical screening of crude leaf and pericarp aqueous extracts of both the plants revealed the presence of tannins, steroids and flavonoids. The results indicate that the aqeueous leaf and pericarp extracts of Ricinus communis and Punica granatum might be exploited as natural drug for the treatment of several infectious diseases caused by these organisms
Authors and Affiliations
Pranay Jain1* and Gulhina Nafis2
Keywords
Related Articles
- EP ID EP85747
- DOI -
- Views 125
- Downloads 0
Management of hypertension in pregnancy: A review
Hypertension in pregnancy is the most common cause of maternal death, with a risk of approximately 10 deaths / million pregnancies in the UK. Hypertension in pregnancy is also the most common cause of stillbirth and neon...
Emergence of ‘Super Bug’ and Use of Antibiotics: What We Learned, What We Have Yet to Learn?
Recent reports on emergence of a multidrug resistant ‘superbug’ have given the world a warning call against irrational use of antimicrobials. Few examples of most dangerous bugs include MRSA, Klebsiella Penumonia, vancom...
Standardization of Neorise Granules
In recent years there is a spurt in the interest regarding survival of Ayurvedic forms of medication. In the global perspective, there is a shift towards the use of medicine of herbal origin, as the dangers and the sh...
Phytochemical analysis and Antimicrobial activities of different plant parts of Vitex negundo L
In the present work leaf and bark extracts of V. negundo were screened for antibacterial and anticandidal property. Qualitative phytochemical analysis, agar cup method, micro-dilution method for MIC, TLC bioautography w...
Phytochemical investigation & evaluation for antidiabetic activity of leafy extracts of various Ocimum (Tulsi) species by alloxan induced diabetic model
The various species of Ocimum (Lamiaceae) i.e. Ocimum gratissimum linn., Ocimum americanum linn., Ocimum sanctum linn. and Ocimum basilicum linn. are widely distributed in tribal areas of south eastern Odisha and extensi...