IN VIVO AND IN VITRO ANTI-FERTILITY AND ANTI-IMPLANTATION PROPERTIES OF LEONOTIS OCYMIFOLIA IN RATS
Journal Title: African Journal of Traditional, Complementary and Alternative Medicines - Year 2005, Vol 2, Issue 2
Abstract
The anti-fertility effect of the aqueous and ethanol extracts of the leaves and roots of Leonotis ocymifolia were studied both in vivo and in vitro. The anti-implantation and anti-fertility activities of the ethanol leaves extract were 37% and 20%, respectively. The body weight recorded for 19 days starting from day 1 of pregnancy showed that all rats of the control groups showed considerable weight gains over the period of 19 days. The weight gained by the rats treated with aqueous root extract was significantly less as compared to the controls. On the contrary, those treated with both aqueous and ethanol leaf extract did not show a significant difference in their weight gains over the same period. Aqueous root and leaf extracts reduced the number of implants significantly. No significant difference was, however, observed between the average number of implants counted in rats treated with ethanol leaf extract and the control group. All extracts were observed to increase acetylcholine induced uterine contraction. The mean percentage contractions showed by these extracts in the presence of acetylcholine were significantly different from that of acetylcholine alone (P < 0.05). The results of this study suggest that the leaves and roots of this plant may possess hormonal properties that can modulate the reproductive function of the rats.
Authors and Affiliations
Geremew Tafesse, Yalemtsehay Mekonnen, Eyasu Mekonnen
Keywords
Related Articles
- EP ID EP128723
- DOI -
- Views 74
- Downloads 0
The antiulcer effects of the methanol extract of the leaves of <i>aspilia africana</i> (asteraceae) in RATS
[i]Aspilia africana,[/i] (Asteraceae) is a plant currently used in Cameroon ethnomedicine for the treatment of stomach ailments. The methanol extract of the leaves of [i]A. africana[/i] was investigated against gastric u...
An investigation on antimicrobial activity of endemic <i>origanum solymicum</i> and origanum bilgeri from Turkey
The methanol extracts obtained from endemic [i]Origanum solymicum[/i] P. H. Davis and [i]Origanum bilgeri[/i] P. H. Davis have been investigated for their antimicrobial activity. Antimicrobial activity was determined Esc...
EFFECT OF EREMOMASTAX SPECIOSA ON EXPERIMANTAL DIARRHOEA
This study investigated the anti diarrhoeal activity of the aqueous extract of dried ground leaves of Eremomastax speciosa (Hochst.) Acanthaceae. Diarrhea was induced in mice by the administration of 0.2 ml of castor oi...
ANTIHYPERGLYCEMIC AND RENAL PROTECTIVE ACTIVITIES OF ANACARDIUM OCCIDENTALE (ANACARDIACEAE) LEAVES IN STREPTOZOTOCIN INDUCED DIABETIC RATS.
Earlier studies from our laboratory have indicated hypoglycaemic action of Anacardium occidentale (AO) leaves in experimental type 1 diabetes. Streptozotocin-induced diabetes in rats had been shown to be associated with...
Antibacterial, anti-inflammatory and diuretic effect of flavonoids from <i>marchantia convoluta</i>
Dried leaves of [i]Marchantia convoluta[/i] are largely used to protect livers, and to treat tumefaction of skins in China. Flavonoids from [i]Marchantia convoluta[/i] (MCF) were the active components against hepatitis B...