INFLUENCE OF DIFFERENT CHANGES ON BIOAVAILABILITY OF MEDICINE CHITOSANS ANTIPHLOGISTIC DRUGS
Journal Title: Progress on Chemistry and Application of Chitin and its Derivatives - Year 2008, Vol 0, Issue
Abstract
The increased adsorption of anti-inflammatory drugs on polymer with pH increased from 7.6 to 8.0 may be explained by the swelling properties of chitosan, which increase with increasing environmental pH to alkaline levels, in which the compound occurs in the form of emulsion, what increases the surface of the polymer and its sorption capacity. Basing on the above considerations, it can be stated that the investigated drug interacts with the polymer; the interaction is of an antagonistic character and consists in adsorption of the drugs on a polymer such as chitosan.
Authors and Affiliations
Jan Meler
VISCOMETRIC STUDIES OF CHITOSAN/POLYACRYLAMIDE MIXTURES
Polymer-polymer interactions and miscibility for chitosan (Ch) and partially hydrolysed polyacrylamide (HPAM) have been investigated using dilute solution viscosity. The intrinsic viscosity, [η], and the viscosity intera...
THE INFLUENCE OF DIFFERENT KINDS OF CHITOSAN ON BIOAVAILABILITY OF ANTI-INFLAMMATORY DRUGS
Chitosan as a dietary supplement has been used in the treatment of obesity due to its capability of binding bioactive compounds. A molecule of a cationic polymer, such as chitosan, may bind acid drugs. The aim of the stu...
THE INFLUENCE OF THE TYPE SOLVENT ON THE STRUCTURE OF CHITOSAN BLENDS WITH HYALURONIC ACID
The influence of the type solvent on the structure of chitosan, hyaluronic acid and their blend films was investigated. Aqueous acetic acid, hydrochloric acid, sodium chloride and aqueous acetic acid/NaCl were used as so...
MOLECULAR STRUCTURE AND FORMATION OF CHITOSAN AND PECTIN BASED THIN FILMS
In this study using methods of Atomic force microscopy (AFM) and Quartz crystal microbalance with dissipation monitoring (QCM-D) the special characteristics of formation and architecture of thin films coatings based on n...
STUDIES OF NORFLOXACIN ADSORPTION ON CHITOSAN
assisting weight loss are used in the obesity treatment. These measures swell in the digestive tract and form the polymer gel system, which has the ability to adsorb up to 5 times more lipids relative to its own weight....