METHOD FOR PREPARATION OF HYBRID SPHERICAL CHITOSAN/POLY(LACTIC ACID) STRUCTURES
Journal Title: Progress on Chemistry and Application of Chitin and its Derivatives - Year 2008, Vol 0, Issue
Abstract
The novelty of preparation is combining two biopolymers into one hybrid system to obtain desired release kinetics of active substances. The substance can be enclosed in the porous PLA microspheres or in the chitosan matrix. The hybrid system demonstrates a high stability in the aqueous environment which indicates some interaction between hydrophobic (PLA) and hydrophilic (CS) composite components. An increase in the beads stability on swelling, by adding PLA allows to reduce or eliminate the chitosan cross-linking agents, for example, toxic glutaraldehyde. The future work will be concentrated on optimization of the emulsification method combined with the organic solvent diffusion in order to obtain a narrow size distribution of PLA microstructures. Additionally, it is crucial to carry out the analysis of the loading effectiveness and the kinetics of a model substance release from a system. The mathematical model of the erosion process with a simultaneous release of an active substance to the aqueous environment of various pH values will be derived
Authors and Affiliations
Jacek Balcerzak, Maria Mucha
Keywords
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