INTERACTION OF EBOLA VIRUS WITH INNATE AND ADAPTIVE IMMUNE SYSTEM: AN IN SILICO STUDY
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 5
Abstract
Objective: Ebola virus (EBOV) is an extremely pathogenic, that can cause severe hemorrhagic fever in human with case fatality rates of up to 90% for which no vaccine or treatment is currently available. The mechanism underlying this lethal outcome is still unclear. However, an alteration of the immune responses represents one of the most important pathogenic mechanisms of Ebola virus infection. EBOV encodes two different proteins (VP24 and VP35) that block the induction of immune responses. Thus, we explored the potential interaction of Ebola virus proteins (VP24 and VP35) with the Toll-like receptor and MHC-1 receptor.Methods: The interaction of Ebola virus protein towards immune system has been checked by Cluspro 2.0.Results: Our results indicated that the Ebola Virus proteins (VP 24 and VP 35) have good interaction towards the Toll-like receptor (TLR-3) and MHC-1 which are a crucial component of innate and adaptive immune system.Conclusion: The findings of this study will be helpful for researchers to design drugs or vaccines for the treatment/prevention of EBOV infections.Keywords: Ebola Virus, Innate Immune system, Adaptive Immune system
Authors and Affiliations
Sony Jacob K.
Keywords
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