Investigation of antidepressant and anxiolytic activity of curcumin given alone and in combination with amitriptyline in rats
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 3
Abstract
The objective of the present study was to evaluate and investigate the antidepressant and anxiolytic activity of curcumin given alone and in combination with amitriptyline in rats. The investigation of antidepressant activity was carried out using Despair Swim Test (DST) and Tail Suspension Test (TST) and for anxiolytic activity Open Field Test (OFT) and Elevated Plus Maze Test (EPM) at 14th day. Wistar albino male rats were divided into six groups consisting six animals each. Control Group I received 2% Gum Acacia (Vehicle control), standard groups Group II and Group III recieved Amitriptyline (AMI) 10 mg/kg and Curcumin (CUR) 70 mg/kg respectively and combination groups Group IV, V and VI received CUR 35 mg/kg + AMI 5 mg/kg, CUR 70 mg/kg + AMI 5 mg/kg and CUR 70 mg/kg + AMI 10 mg/kg respectively for 14 days. Duration of immobility and locomotion, number of rearings, number of squares crossed, and time, spend and number of entries in open and closed arms was evaluated for antidepressant and anxiolytic activity respectively. Combination therapy of curcumin and amitriptyline showed significant decrease in duration of immobility in DST and TST, increase in locomotion, number of rearings and squares crossed in OFT and increase in number of open arm entries and time spend in open arm in EPM as compared to control and standard group of curcumin and amitriptyline alone. The results revealed that curcumin when given in combination with amitriptyline showed synergistic antidepressant and anxiolytic activity, which may reduce side effects of amitriptyline in chronic depressive patient.
Authors and Affiliations
Pankti Patel, Kashmira J Gohil, Samaresh Pal Roy, Nikunj P
Keywords
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