ISOLATION OF MULTIDRUG RESISTANT (MDR) BACTERIA & HEMODYNAMIC STABILITY ON THE DAY OF STARTING OF ANTIBIOTICS
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2017, Vol 6, Issue 1
Abstract
There is a generalized assumption among clinicians that the hemodynamically unstable patients are mostly infected with the multidrug resistant organisms compared to the hemodynamically stable patients, and that is why the patients who are considered to be hemodynamically less stable, are empirically prescribed with the broad spectrum antibiotics. This hypothesis has not been supported by any valid evidence yet .So the aim of our study was to find the association of the hemodynamic status of patients with the drug resistance pattern of organisms and the prescribing pattern of antibiotics. In the present study it has been found that the MDR organisms were isolated more frequently from hemodynamically unstable patients compared to the stable patients (70% Vs 63.25%). However the difference is not statistically significant. Interestingly in case of bacteremia, significantly higher no. (p=0.001) of hemodynamically unstable patients have been infected with MDR organisms. Moreover another significant finding of the study is that the hemodynamically unstable patients have been mostly prescribed with broad spectrum antibiotics like Colistin (p=0.031) and combination of multiple groups of antibiotics (p=0.004) than the stable ones. So the study may provide an important indication for the correlation of hemodynamic stability with multidrug resistance and antibiotic prescription pattern.
Authors and Affiliations
Tapan Kumar Chatterjee
Keywords
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