KINETICS OF ACTIVE SUBSTANCE RELEASE FROM FLAT BIOPOLYMER MULTILAYER FILMS
Journal Title: Progress on Chemistry and Application of Chitin and its Derivatives - Year 2010, Vol 0, Issue
Abstract
Abstract. Polymer films were made of different biodegradable materials. Solid support of model active substance (salicylic acid) was unmodified and modified (crosslinked with glutaraldehyde) chitosan and outside layers were polylactid acid (PLA). The aim of the study was to obtain the controlled release kinetics of active substance, in medium of pH 5.6 which is similar to conditions occurring on the human skin surface. The chitosan films were investigated with swelling kinetics while multilayer films were studied with release kinetics of active substance (salicylic acid). The amount of salicylic acid released from film was measured using a UV-VIS spectrophotometer. The appropriate mathematical model was also adjusted to the experimental points. The results prove that the swelling process follows the first order kinetics but the results of release process are fitted with Peppas model.
Authors and Affiliations
Iwona Michalak, Dariusz Traczyk, Maria Mucha
Keywords
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