Lack of association between the development and clinical course of Type 1 and Type 2 Diabetes Mellitus and rare T130I variant of the HNF4A gene in the Polish population
Journal Title: Journal of Pre-Clinical and Clinical Research - Year 2016, Vol 10, Issue 1
Abstract
Type 2 diabetes (T2DM) is a multifactorial disease related to both environmental and genetic factors. While environmental factors leading to the development for T2DM are well established, the majority of factors responsible for the genetic background of the disease remain unknown. The aim of this study was to test whether a rare variant within the HNF4A gene, Thr130Ile (rs1800961), may influence the development of clinical course of T1DM or T2DM subjects. The analysis included 574 patients with T2DM, 207 T1DM individuals and 284 healthy controls. All subjects were genotyped for the Thr130Ile polymorphism in HNF4A. For T2DM, no differences were found in allele frequencies between cases and controls. The percentage of CT genotype in these groups were 5.7% (33 patients) and 5.6% (16 healthy controls), respectively (p=0.89). For T1DM, the allele frequency was not statistically different from T2DM or control subjects. In conclusion, no association was found between rare variant Thr130Ile of the HNF4A gene and the development of either T2DM nor T1DM in the Polish population.
Authors and Affiliations
Małgorzata Grzanka, Bartłomiej Matejko, Tomasz Klupa, Maciej Malecki
Keywords
Related Articles
- EP ID EP79302
- DOI 10.5604/18982395.1208192
- Views 82
- Downloads 0
Analysis of the impact of education level on the sense of coherence and opinion concerning carrying out preventive vaccination
[b]Introduction[/b]. Nowadays, preventive vaccination is still the most effective method of countering and combating infectious diseases. Objective. The objective of the present study was to take into consideration the...
Alpha-ketoglutarate partially protects newborns from metabolic changes evoked by chronic maternal exposure to glucocorticoids
Foetal and neonatal time is very important for the growth and development of the mechanisms involved in the programming of metabolic processes in adult life. In foetal life, critical developmental time-windows for differ...
The weaning-related changes in amino acids status of blood plasma in piglets
The aim of this study was to investigate changes of hormones and plasma amino acids in piglets subjected to weaning procedure. Twelve male piglets (Large Polish White breed) were used in the experiment. Piglets were hel...
Human tuberculosis in colonial Victorian and present-day Britain
Tuberculosis (TB) (consumption) is a particularly unpleasant disease that has seen a re-emergence in Britain, especially among immigrant populations. The objective of the review was to consolidate the principal and impo...
Effect of environmental parameters on the concentration of nickel (Ni) in bones of the hip joint from patients with osteoarthritis
[b]Introduction.[/b] Bone trace elements levels including nickel (Ni) depend on biological and environmental factors: age, gender, remodeling state, exposure to occupational and environmental pollution, smoking, diet, an...