Lipid profile in Type 2 diabetes mellitus and in diabetic nephropathy
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2017, Vol 4, Issue 4
Abstract
Introduction: Diabetes mellitus (DM) is characterized by abnormalities of carbohydrate, protein and fat metabolism due to absolute or relative deficiency of insulin secretion, accompanied by varying degrees of resistance to insulin. Diabetes mellitus is currently the most common etiology for chronic kidney disease (CKD). Abnormalities of lipoprotein metabolism is associated with Diabetic nephropathy(DN), which can be influenced by derangement of renal function and the degree of metabolic control in diabetes mellitus. Our objective is to compare the levels of lipid profile, urine microalbumin and glycated haemoglobin (HbA1c) between type 2 Diabetes mellitus (T2DM) without any complications, T2DM with nephropathy and normal controls who were age and sex matched. Materials and Method: Study group consisted of 75 individuals of whom 25 were T2DM without any complications, 25 were T2DM with nephropathy and 25 were healthy controls. Total cholesterol (TC), Triglycerides(TG), LDL Cholesterol(LDL-c), HDL Chlolesterol (HDL-c), HbA1c and urine microalbumin were measured in these subjects. Results: The values of TC, TG, LDL-c, HbA1c and urine microalbumin levels were significantly higher in T2DM without any complications and T2DM with nephropathy when compared to controls. HDL- c level was significantly lower in T2DM without any complications and T2DM with nephropathy when compared to controls. Conclusions: T2DM and DN are associated with dyslipidemia which is more pronounced in diabetic nephropathy. Therefore, early detection of dyslipidemia in Type 2 diabetics and accordingly therapeutic intervention could control the resulting cardiovascular or renal complications.
Authors and Affiliations
Srinidhi Rai, Prajna K, Tirthal Rai
Keywords
Related Articles
- EP ID EP297980
- DOI 10.18231/2394-6377.2017.0086
- Views 53
- Downloads 0
Study of emergency laboratory parameters in acute oraganophosphorus poisoning in a rural population- retrospective study
Introduction Organophosphorus poisoning OPP is one of the common medical emergencies among rural population in India due to suicide attempts The purpose of this study was to investigate the relationship between the initi...
Biochemical markers of renal and hepatic function in gestational diabetes mellitus
Aim: To assess the biochemical parameters of renal and hepatic function in women with GDM and compare the results with those of normal pregnant women. Materials and Methods: Cases: The study group consisted of 45women wi...
Application of failure mode and effects analysis to minimize quality failures in clinical biochemistry laboratory
Introduction Quality failures in the clinical laboratories should be analyzed to improve patient safety in hospital Purpose of this study is to apply failure mode and effects analysis FMEA for prospective risks of qualit...
Serum ferritin level in type 2 diabetes mellitus - A case control study
Background: Hyperferritinemia probably contributes insulin resistance and subsequently to decreased insulin secretion causes for development of insulin resistance. Objectives: Compare HbA1c with Ferritin and find correla...
Assessment of various calculation methods for measurement of LDL-Cholesterol
Background: Coronary Artery Disease is the leading cause of death worldwide and LDL has been recommended as the primary lipid subset for prediction of risk of CAD NCEP guidelines. Many assays have been developed for meas...