Lipid profile in Type 2 diabetes mellitus and in diabetic nephropathy
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2017, Vol 4, Issue 4
Abstract
Introduction: Diabetes mellitus (DM) is characterized by abnormalities of carbohydrate, protein and fat metabolism due to absolute or relative deficiency of insulin secretion, accompanied by varying degrees of resistance to insulin. Diabetes mellitus is currently the most common etiology for chronic kidney disease (CKD). Abnormalities of lipoprotein metabolism is associated with Diabetic nephropathy(DN), which can be influenced by derangement of renal function and the degree of metabolic control in diabetes mellitus. Our objective is to compare the levels of lipid profile, urine microalbumin and glycated haemoglobin (HbA1c) between type 2 Diabetes mellitus (T2DM) without any complications, T2DM with nephropathy and normal controls who were age and sex matched. Materials and Method: Study group consisted of 75 individuals of whom 25 were T2DM without any complications, 25 were T2DM with nephropathy and 25 were healthy controls. Total cholesterol (TC), Triglycerides(TG), LDL Cholesterol(LDL-c), HDL Chlolesterol (HDL-c), HbA1c and urine microalbumin were measured in these subjects. Results: The values of TC, TG, LDL-c, HbA1c and urine microalbumin levels were significantly higher in T2DM without any complications and T2DM with nephropathy when compared to controls. HDL- c level was significantly lower in T2DM without any complications and T2DM with nephropathy when compared to controls. Conclusions: T2DM and DN are associated with dyslipidemia which is more pronounced in diabetic nephropathy. Therefore, early detection of dyslipidemia in Type 2 diabetics and accordingly therapeutic intervention could control the resulting cardiovascular or renal complications.
Authors and Affiliations
Srinidhi Rai, Prajna K, Tirthal Rai
Keywords
Related Articles
- EP ID EP297980
- DOI 10.18231/2394-6377.2017.0086
- Views 36
- Downloads 0
Evaluation of coagulation profile in patients suffering with type-2 diabetes mellitus: A hospital based prospective study
Introduction: T2DM and its complications develop due to uncontrolled plasma glucose levels for long time. Long term hyperglycemia will cause glycation of various tissue proteins. It also affects the coagulation process a...
Obesity, obesity related hypertension, their association with adipocytokines among 12-16 years school students
Obesity, obesity related hypertension is increasing at higher rates among adolescents these days. An increase in leptin level and a decrease in adiponectin level were observed in obese individuals with hypertension. Our...
Educating people about the healthy edible oils and its storage practices can reduce the incidence of metabolic syndrome: A KAP study
Background: The use of edible oils depends on the traditional practices, educational and socio-economic status. There is a need to educate people regarding the harmful effects of saturated, trans fatty acids, proper stor...
Dendritic cells and vitamin D in dry eye disease
To study the role of dendritic cells and vitamin D in troublesome evaporative dry eye diseasesMaterials and Methods This is a cross sectional study which includes 108 patients having evaporative dry eye disease and 86 no...
Study of serum copper and zinc in diabetic retinopathy and its correlation with glycemic status
Background: Diabetes Mellitus (DM) is a global public health problem. It is associated with increased level of free radicals which lead to oxidative stress and dangerous complications like retinopathy. Trace elements hav...