Abstract

The present research deals with liposome are formulated with diclofenac sodium. Liposomes are sphere shaped vesicles containing one or more phospholipids bilayer, these are usually used to maintain drugs from any concentrations at target sites for alonger period of time (sustained effect) & even increase the bioavailability of the drug. The main reason to formulate diclofenac sodium into liposome is that diclofenac has a plasma t1/2 of 2-3 hours and there is a need for patients to administer the drug 2-3 times a day to persist the desired effect. We have produced liposomes using thin film hydration technique & different excipients like cholesterol, soya lecithin were used. When they were formulated as liposome it showed asustained effect when evaluated in vitro.The different evaluation studies like particle size determination, vesicular entrapment, drug release profile, SEM studies and FTIR spectrum studies were done in this research & these tests were used as parameters to determine the optimized formulation and even the sustain release effect of the system.

Authors and Affiliations