McIndoe Operation without Skin Graft: A New Neovaginal Prosthesis of Polylactic Acid (PLA)
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 18, Issue 9
Abstract
Historically, the creation of a neovagina with an inert prosthesis or synthetic mold and a split-thickness skin graft (McIndoe´s technique) has been the most common surgical procedure. The major inconvenient of this technique are those related with: 1) Making the skin graft and the permanent scar in the donor area; and 2) The prostheses used as mold; the material might be of certain weight and stiffness that can produce bedsore on the recto-vaginal septum or necrosis of the lowest portion of the urethra and hypospadias. To avoid the skin graft, currently, good results have been achieved by simply covering the prosthesis with Interceed®. And regarding the neovaginal prostheses, we have designed a new prototype of prosthesis anatomically adapted to the vagina of normal women and besides being lightweight, and designed with 3D technology it is made of polylactic acid (PLA, biodegradable polymer derived from lactic acid) that contributes to the epithelialisation of the vagina, and which has been patented and presented in 2nd International Meeting on Rokitansky syndrome (Warsaw, Poland, 26-28 May 2016). The main advantages of the modification of the McIndoe´s technique include: 1) The neovagina might be done without skin graft, ie, using only the PLA prosthesis and a biocompatible and biodegradable mesh (used as biogenerative scaffold), thus allowing an almost outpatient surgery, more easy, without further dermal scarring and providing women more comfort and functionality. And 2) Instead 8-9 days of admission to make cures at donor skin graft area, the patient can go home the next day. The McIndoe surgical procedure might then be the most appropriate, simplest and with best anatomical, sexual and psychological results of the surgical techniques for neovagina.
Authors and Affiliations
Pedro Acién, Maribel Acién, Miguel-Angel Oliva-Meyer, Miguel Sánchez-Lozano, Javier Martínez-Garcia
Plant-derived Tetranortriterpenoid, Methyl Angolensate Activates Apoptosis and Prevents Ehrlich Ascites Carcinoma Induced Tumorigenesis in Mice
Background: Cancer is a leading health problem throughout the world. For decades, natural plant products have been playing promising roles as anticancer agents. Objective: The present study aims to investigate the chemo...
Adapted Technological Platform for Screening and Identifying Compounds Capable of In vivo Spinal Network-mediated Reflex Ejaculation in Non-anesthetized, Chronic Paraplegic Mice: Evidence of Clonidine-elicited Seminal Emission
Several drugs have been shown to facilitate locomotor rhythmogenesis and treadmill training after Spinal Cord Injury (SCI). Clonidine, an alpha-adrenoceptor agonist, is of particular interest given its well-known effects...
Correlation of Spot Urine Protein:Creatinine Ratio with 24-hour Urinary Protein in Preeclampsia: A Cross Sectional Study
Aims: The present study was undertaken to evaluate the diagnostic value of protein:creatinine ratio in spot voided urine sample for detection of proteinuria as compared to those of 24 hour urine sample in patients with...
A Prospective Drug Utilization Study in Geriatric Hypertensive Patients in a Tertiary Care Hospital, Mumbai
Introduction: The geriatric population assumes great significance in terms of both preventive and curative health care services utilized. The patho-physio-psychological changes associated with ageing make their problems...
Evaluation of Commercial Rapid Diagnostic Test Kit for Tuberculosis: Further Evidence Supporting Negative Policy on the Use of Serological Tests for Pulmonary Tuberculosis Diagnosis in Developing Countries
Aim: To know whether one of the commercially available immunochromatographic tuberculosis tests is comparable with the widely available method, direct sputum microscopy. Design: The study prospectively validated the pulm...