Molecular classification of breast cancer in Egyptian cohort: 10 years follow-up and survival
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 8
Abstract
Background:Molecular classification of breast cancer has been used recently beyond the conventional pathologic grade and histology. This resulting in classifying breast cancer into different molecular subtypes, understanding that clarify different risks of relapse and response to adjuvant therapies in patients. This also demonstrates that breast cancer subtypes are associated with unique patterns of metastatic spread with differences in relapse and survival. Patients and Methods: a retrospective cohort study of all nonmetastatic breast cancer patients diagnosed and/or treated at National Cancer Institute, Cairo University from January to December 2003. Results: The most common molecular class was Luminal A (34%), and least was Luminal B HER2 enriched (10.7%). TN and HER2 enriched being more aggressive tumours were significantly associated with higher recurrence rate than other luminal classes (p = 0.003). The median DFS was 47.4 months. The median TLR of all patients was 88.4 months. The 5-year TLR was significantly longer in luminal class A (83.7%) than HER2 enriched (40.6%), p=0.001. Conclusion: TN and HER2 enriched being more aggressive tumours were significantly associated with higher recurrence rate than other luminal classes. The median DFS was 47.4 months. The median TLR of all patients was 88.4 months. The 5-year TLR was significantly longer in luminal classes than HER2 enriched, denoting bad prognosis of this molecular class.
Authors and Affiliations
Omnia M. Abo- Elazm, Dalia Bilal, Eman Gouda, Mosaad M. El Gammal, Salem Eid Salem, Nelly H. Alieldin
Keywords
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- EP ID EP381461
- DOI 10.9790/0853-1708115764.
- Views 43
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