CLINICAL EVALUATION OF EFFICACY OF SERTACONAZOLE 2% CREAM IN TREATMENT OF PITYRIASIS VERSICOLOR AND A COMPARISION WITH THAT OF CLOTRIMAZOLE 1% CREAM
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2015, Vol 4, Issue 27
Abstract
[b] BACKGROUND[/b]: Pityriasis versicolor is a mild superficial, chronic recurrent fungal infection. Many topical agents have been used with varying degree of success and high recurrence rate. The current study was conducted to clinically evaluate the efficacy of sertaconazole 2% in treating and preventing recurrences of pityriasis versicolor as compared to clotrimazole1%cream. [b]AIMS[/b]: Clinical evaluation of the efficacy of sertaconazole 2% cream in the treatment of pityriasis versicolor and its comparison with that of clotrimazole 1% cream. [b]MATERIALS & METHODS[/b]: 110 patients who were diagnosed clinically and microscopically as pityriasis versicolor and fulfilling the criteria were enrolled, of which 55 were treated with 2% sertaconazole cream and 55 with 1% clotrimazole cream twice daily for 4 weeks. At the end of fourth week patients were examined both clinically and mycologically. Follow up was done at 6 weeks to note any relapse clinically and mycologically.[b] RESULTS[/b]: Out of 110 patients 4 patients using sertaconazole, 6 patients using clotrimazole were lost for follow-up and excluded from the study. Global assessment was done at the end of treatment i.e., 4 weeks with clinical and mycological cure rate, revealed that 42(82.3%) of the sertaconazole group, 30(61.2%) of the clotrimazole group were improved clinically. Mycological examination at the same time was negative in 44(86.3%), 33(67.4%) respectively. 7(13.7%) of sertaconazole group, 12(24.48%) of clotrimazole group show no significant change. 4(8.16%) patients using clotrimazole complained of deterioration of symptoms but none using sertaconazole. [b]CONCLUSION[/b]: Comparing the results obtained in this trial showed that sertaconazole was more efficacious than clotrimazole in the treatment of pityriasis versicolor because of its direct membrane damaging effect. But in terms of pigmentary resolution sertaconazole is not comparable to clotrimazole cream due to persistent effect of azelic acid.
Authors and Affiliations
Lakshmi Tatavarthi, Ramachandra B. V, Subba Rao, Srinivasulu G
Keywords
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- EP ID EP95596
- DOI 10.14260/jemds/2015/675
- Views 73
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