A REVIEW ON CLINICAL MANAGEMENT OF MULTIPLE SCLEROSIS
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2011, Vol 1, Issue 2
Abstract
Multiple sclerosis affects the ability of nerve cells in the brain and spinal cord to communicate with each other. Nerve cells communicate by sending electrical signals called action potentials down long fibers called axons, which are wrapped in an insulating substance called myelin. In Multiple sclerosis, the body own immune system attacks and damages the myelin. When myelin is lost, the axons can no longer effectively conduct signals. Multiple sclerosis is characterized by inflammation and demyelination of white matter in the brain and spinal cord. The myelin sheath influences the rate of nerve impulse conduct with transmission being more rapid in myelinated nerve fibers. In Multiple sclerosis, an auto immune response is evoked that causes the body to attack its own myelin. The disease is usually characterized by a relapsing remitting course in the early stages, with full or nearly full recovery initially. It is known from previous studies of the natural history of Multiple sclerosis, that a high frequency of clinical relapses over the first years is associated with an increased risk of later deterioration. Based on this observation and the inflammatory reactions described in Multiple sclerosis there are reasons to initiate treatment as early as possible to prevent axonal damage and irreversible damage.
Authors and Affiliations
G. Balammal , G. Sangeetha , M. Sekar Babu , L. Mohan Krishna , G. Aruna
Keywords
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