ANTI-CATALEPTIC ACTIVITY OF ETHANOL EXTRACT OF VERNONIA CINEREA L.
Journal Title: Asian J of Pharm Sci & Tech - Year 2012, Vol 2, Issue 1
Abstract
ABSTRACT The plants of the genus Vernonia (Asteraceae) are widely distributed in most tropical and subtropical countries, and have long been used in traditional medicine to treat various types of diseases. In recent years, the interest in the plant-based medicine has increased noticeably worldwide. In the present study we evaluated the anticataleptic efficacy of ethanol extract of Vernonia cinerea L. in haloperidol induced catalepsy in rats. Scientific evaluation of this claim using experimental model Anticataleptic activity using block method, Locomotor activity in actophotometer and Exploratory behavior in hole board apparatus. From the observations of above studies it could be envisaged, that the protective effect of ethanol extract of Vernonia cinerea L. against symptoms of Parkinson’s disease (catalepsy) may be due to regulation in neurotransmitters such as dopamine, serotonin, glutamate which are playing an important role in protection of catalepsy and antioxidant properties. Further studies have to be conducted on the various extracts and isolated principles of the plant for their effects on other CNS disorders. Keywords: Vernonia cinerea L., catalepsy, Parkinsonism, CNS disorders.
Authors and Affiliations
*P. Jayachandra Reddy, V. Prabhakaran, K. Umasankar, M. Sekar Babu
Keywords
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