DEVELOPMENT OF FORMULATION AND IN-VITRO EVALUATION OF GASTRO RETENTIVE FLOATING DRUG DELIVERY SYSTEM FOR NITRENDIPINE BILAYER TABLETS
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2016, Vol 6, Issue 1
Abstract
ABSTRACT The developing of formulation for Floating bilayer tablets of Nitrendipine. IR and SR layers were compressed as direct compression method. IR and SR Layers were evaluated for pre and post compression studies. Those all studies were found to be within limits. From the dissolution data of Nitrendipine Immediate release Layer, IR2 formulation was shown maximum drug release at 15 min. i.e., 95.62%. Hence IR2 was concluded as optimized formulation for IR layer. From the dissolution data of floating bilayer tablets of Nitrendipine, FT5 (IR2&SR5) has shown good drug release 97.12% upto 12 hrs. SR5 contain Locust bean gum. Optimised SR5 Layers were kept for release kinetic studies. SR5 Layer was following Kars mayer peppas release kinetics. Keywords: Nitrendipine, SR floating layer, Floating bilayer tablets.
Authors and Affiliations
P. Gopalakrishna1 *, B. Ramarao1 , G. Chiranjeevi1 , S. Ramyasri2
Keywords
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