FORMULATION AND EVALUATION OF GLIMEPIRIDE MICROSPHERES
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2013, Vol 3, Issue 1
Abstract
The present study is an attempt to formulate microspheres of Glimepiride, an orally administered ant-diabetic drug with a view of improving its oral bioavailability and giving a prolonged release of drug, where here the microspheres with polymers such as Ethyl cellulose and Eudrajit RS 100 and Eudrajit RL 100 were successfully prepared by emulsification solvent evaporation method and the particle size analysis revealed that the size of microspheres was increased with increase in the concentration of polymer. Formulation with combination of Ethyl cellulose, Eudrajit RS 100 and Eudrajit RL 100 gave large particles in the range of 250.6±1.34 µm, Scanning electron microscopy showed that microspheres of drug with combination of Ethyl cellulose, Eudrajit RS 100 and Eudrajit RL 100 showed smooth surface and a good spherical shape where the in-vitro drug release studies showed that drug release was more in case of formulations MP9- MP12 containing both hydrophilic and hydrophobic polymers as compared to formulations MP1- MP8 only hydrophobic polymer.
Authors and Affiliations
N. Sriram , R. Hima Bindu
Keywords
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