FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET BY INCLUSION COMPLEXATION
Journal Title: Asian J of Pharm Sci & Tech - Year 2014, Vol 4, Issue 1
Abstract
ABSTRACT Glimepiride (GMP) is third Generation sulphonyl ureas used for treatment of type 2 diabetes. Poor water solubility is the main constant for its oral bioavailability. The rationale of this study to enhance solubility and dissolution of the drug by preparing its complex with β cyclodextrin. In the present study attempt has been made to prepare, formulate and characterize inclusion complex of glimepiride with β cyclodextrin. The inclusion complex prepared by kneading method. The inclusion complex containing Glimepiride:β cyclodextrin (1:5) was further formulated into fast dissolving tablet by direct compression technique using superdisintegrant like sodium starch glycolate. The prepared complex were characterize using FT-IR, DSC and finally fast dissolving tablet were evaluated for various pharmaceutical characteristics viz. Hardness, % Friability, Weight variation, Wetting time, Drug content and in-vitro dissolution profiles. Key words: Fast dissolving tablet, Glimepiride, Kneading method, β cyclodextrin superdisintegrants.
Authors and Affiliations
Narendra Rajput, VM Thakare*, BW Tekade, KP Chaudhari, UT Jadhao
Keywords
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