SCREENING OF PHYTOCHEMICAL AND ROLE OF BARRINGTONIA ACUTANGULA (L.) EXTRACTS ON BIOGENIC AMINES CONCENTRATIONS IN RAT BRAIN
Journal Title: Asian J of Pharm Sci & Tech - Year 2014, Vol 4, Issue 1
Abstract
ABSTRACT The leaves of Barringtonia acutangula (L.) are used traditional Indian medicine to treat epilepsy. Previous studies have demonstrated that extracts of these plants was subjected to acute toxicity and then screened for antiepileptic activity on Maximal Electroshock (MES) seizures model in albino wistar rats. The purpose of the present study is to investigate the effect of ethanol extract of Barringtonia acutangula (L.) (EBA) on biogenic amines concentrations in rat brain after induction of seizures by MES. Our aim of study was relationship between seizure activities and altered the monoamines such as noradrenaline (NA), dopamine (DA), serotonin (5-HT) in forebrain of rats in MES seizure models. In MES model, EBA (200 & 400 mg/kg) showed significantly restored the decreased levels of brain monoamines such as NA, DA & 5-HT. Thus, this study suggests that ethanol extract of Barringtonia acutangula (L.) increased the monoamines on rat brain, which may be decreased the susceptibility to MES induced seizure in rats. Key words: Antiepileptic activity, Barringtonia acutangula (L.), biogenic amines, NA, DA, 5-HT.
Authors and Affiliations
G. Sandhyarani*, K. Swathi, Gangarapu. Kiran, K. Praveen Kumar, Alli Ramesh
Keywords
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