MULTIVARIATE UV-VISIBLE SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF EMTRICITABINE IN BULK FORM
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2015, Vol 5, Issue 2
Abstract
ABSTRACT To develop a simple, precise and accurate UV-method with multivariate calibration technique for estimation of emtricitabine in bulk form. This technique is based on the use of the linear regression equations by using relationship between concentration and absorbance at five different wavelengths like 287, 289, 291, 293 and 295. The results were treated statistically and were found highly accurate, precise and reproducible. The emtricitabine shows absorption maxima at 291 nm and obeyed Beer’s law in the range of 1-10 µg/mL. The % recovery of capsules was found to be in the range of 99.16-100.41. The low % RSD values are indicates the accuracy and precise of the method. The proposed methods can be successfully applied for method development, validation and multivariate analysis of emtricitabine. Keywords: Emtricitabine, UV spectroscopy, Development, Validation and Multivariate technique.
Authors and Affiliations
K. Vijaya Sri,* M. Madhuri , G. Vinay jain
Keywords
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