Pharmacological studies of anti diarrhoeal activity of Casuarina equisetifolia (L.) in experimental animals
Journal Title: Asian J of Pharm Sci & Tech - Year 2011, Vol 1, Issue 1
Abstract
ABSTRACT The purpose of the present study was to evaluate scientifically the anti-diarrhoeal effects of ethanolic (90%) extract of Casuarina equisetifolia Linn (EECE) was studied against castor oil-induced-diarrhoea model in rats. Antidiarrhoeal activity of 90% ethanol extract of Casuarina equisetifolia was investigated in this study using castor oil-induced-diarrhoea, enteropooling and Small intestinal transit models in rats. The weight and volume of intestinal content induced by castor oil were studied by enteropooling method. Standard drug diphenoxylate (5 ml/kg, p.o) was significant reductions in fecal output and frequency of droppings whereas EECE at the doses of 200 and 400 mg/kg p.o significantly (P<0.001) reduced the castor-oil induced frequency and consistency of diarrhoea and enteropooling. The gastrointestinal transit rate was expressed as the percentage of the longest distance travelled by the charcoal divided by the total length of the small intestine. EECE at the doses of 200 and 400 mg/kg significantly inhibited (P<0.001) the castor oil induced charcoal meal transit. The EECE showed marked reduction in the number of diarrhoea stools and the reduction in the weight and volume of the intestinal contents, as well as a modest reduction in intestinal transit. The results obtained establish the efficacy and substantiate the folklore claim as an anti- diarrheal agent. Further studies are needed to completely understand the mechanism of anti-diarrhoeal action of Casuarina equisetifolia Linn. Keywords: Antidiarrhoeal Activity, Casuarina equisetifolia L., Traditional medicine, Castor Oil- induced diarrhoea, Enteropooling Method, Small intestinal transit.
Authors and Affiliations
K. K. Senthil Kumar
Keywords
Related Articles
- EP ID EP144051
- DOI -
- Views 156
- Downloads 0
DEVELOPMENT AND VALIDATION OF ISOCRATIC RP-HPLC METHOD FOR DETERMINATION OF VENLAFAXINE IN BULK AND TABLET DOSAGE FORM
ABSTRACT A simple, specific, sensitive, convenient, accurate, rapid and reliable isocratic reverse phase high performance liquid chromatographic (RP-HPLC) method has been developed for the quantitative determinat...
THERAPEUTIC PROPERTIES OF MEDICINAL PLANTS: A REVIEW OF PLANTS WITH HYPOLIPIDEMIC, HEMOSTATIC, FIBRINOLYTIC AND ANTICOAGULANT EFFECTS (PART 1)
ABSTRACT The recent studies showed that many plants possessed cardiovascular effects. This review was designed to cover the hypolipidemic, fibrinolytic anti platelet aggregating and antioxidant effects of the med...
A REVIEW: TRANSUNGAL DRUG DELIVERY A NEW AND NOVEL SYSTEM
ABSTRACT The Nail preparations are widely used in cosmetic preparations for enhancing the beauty of nails. Conventional nail lacquers generally consist of solvents, film forming polymers, resins and plasticizers....
SYNTHESIS AND EVALUATION OF NOVEL-3-AMINO-2-ARYL [1,2,4] TRIAZOLO [5,1-b] QUINOZOLIN-9 (3H)-ONES OF BIOLOGICAL INTEREST
ABSTRACT The synthesis of ten novel fused triazoloquinazolinones by making use of 3-amino-2-hydrazino-4 (3H)-quinazolinones as synthon with view to evaluation them for their possible biological and pharmacologic...
CROP PERFORMANCE OF GROUNDNUT (ARACHIS HYPOGAEA L.) PLANTS DEVELOPED FROM DIFFERENT SEED LOTS WITH AN EMPHASIS ON ORGANIC FERTILIZER REGIMES
ABSTRACT A field experiment was conducted at the Eastern region of Sri Lanka to determine the performance of groundnut progeny from plants treated with different fertilizer regimes. Treatments were assigned accor...