SYNTHESIS AND EVALUATION OF NOVEL-3-AMINO-2-ARYL [1,2,4] TRIAZOLO [5,1-b] QUINOZOLIN-9 (3H)-ONES OF BIOLOGICAL INTEREST
Journal Title: Asian J of Pharm Sci & Tech - Year 2012, Vol 2, Issue 1
Abstract
ABSTRACT The synthesis of ten novel fused triazoloquinazolinones by making use of 3-amino-2-hydrazino-4 (3H)-quinazolinones as synthon with view to evaluation them for their possible biological and pharmacological properties. For this purpose, the required 3-amino-2-hydrazino-4 (3H)-quinazolinones prepared from the 3-amino-2-mercapto-4 (3H)-quinazolinone by direct hydrazinolysis/ alkylation followed by hydrazinolysis of 3-amino-2-mercapto-4 (3H) quinazolinone. 3-amino-2-mercapto-4 (3H) quinazolinones are prepared from respective 2-amino benzoic acid. This on condensation with a various benzolylchlorides to get 3-amino-2-aryl [1,2,4] triazolo [5,1-b] quinazolin-9 (3H)-ones, further the free amino group of triazole is condensed with aromatic aldehydes to get Schiff bases. The newly synthesized compounds have been characterized by their analytical and spectral (IR, 1HNMR and Mass) properties. Further, they have been screened for their antibacterial, antifungal, anti-inflammatory (in vitro) and by standard method. Results of the activities reveals that, compounds exhibited moderate to good antibacterial and antifungal activities. Key words: Quinazolinones, Triazoloquinazolinones, Schiff bases, Anti-microbial and Anti-fungal.
Authors and Affiliations
Abdul Kadar Mujahid*, Kalyane N V, Shivkumar B, Hemasundar Naidu M,Pramod N and Rizwan M
Keywords
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