SYNTHESIS AND EVALUATION OF NOVEL-3-AMINO-2-ARYL [1,2,4] TRIAZOLO [5,1-b] QUINOZOLIN-9 (3H)-ONES OF BIOLOGICAL INTEREST
Journal Title: Asian J of Pharm Sci & Tech - Year 2012, Vol 2, Issue 1
Abstract
ABSTRACT The synthesis of ten novel fused triazoloquinazolinones by making use of 3-amino-2-hydrazino-4 (3H)-quinazolinones as synthon with view to evaluation them for their possible biological and pharmacological properties. For this purpose, the required 3-amino-2-hydrazino-4 (3H)-quinazolinones prepared from the 3-amino-2-mercapto-4 (3H)-quinazolinone by direct hydrazinolysis/ alkylation followed by hydrazinolysis of 3-amino-2-mercapto-4 (3H) quinazolinone. 3-amino-2-mercapto-4 (3H) quinazolinones are prepared from respective 2-amino benzoic acid. This on condensation with a various benzolylchlorides to get 3-amino-2-aryl [1,2,4] triazolo [5,1-b] quinazolin-9 (3H)-ones, further the free amino group of triazole is condensed with aromatic aldehydes to get Schiff bases. The newly synthesized compounds have been characterized by their analytical and spectral (IR, 1HNMR and Mass) properties. Further, they have been screened for their antibacterial, antifungal, anti-inflammatory (in vitro) and by standard method. Results of the activities reveals that, compounds exhibited moderate to good antibacterial and antifungal activities. Key words: Quinazolinones, Triazoloquinazolinones, Schiff bases, Anti-microbial and Anti-fungal.
Authors and Affiliations
Abdul Kadar Mujahid*, Kalyane N V, Shivkumar B, Hemasundar Naidu M,Pramod N and Rizwan M
Keywords
Related Articles
- EP ID EP164716
- DOI -
- Views 133
- Downloads 0
MEDICINAL CHASMOPHYTES OF URUMBIKKARA HILLS, IDUKKI DISTRICT, KERALA, INDIA
ABSTRACT The present paper shows 45 species of medico-potential chasmophytes from Urumbikkara Hills of Idukki district, Kerala. These medicinal plants are used either their any part only or the whole plant for th...
THE PHARMACOLOGICAL AND THERAPEUTIC IMPORTANCE OF AGRIMONIA EUPATORIA- A REVIEW
ABSTRACT The phytochemical analysis of Agrimonia eupatoria revealed the presence of carbohydrates, glycosides, tannins, terpenoids, phenolic compounds (flavonoids), agrimony, agrimony lactone, oils and many other...
ETHNOMEDICINAL SURVEY OF YAVATMAL DISTRICT (MS)
ABSTRACT Yavatmal District is rich in ethnomedicinal plants. The present paper deals with study of plants used for ethnomedicinal purposes. The ethnomedicinal data of 50 plants species belonging to 33 families we...
PROPERTIES OF SOIL IN CHHATTISGARH PLAINS (SPECIAL REFERENCE TO DISTRICT BILASPUR)
ABSTRACT The present study is in the direction to estimate the physio- chemical properties of soil before and after cultivation of tomato .the study was carried in Chhattisgarh plains with special reference to Bi...
THERAPEUTIC PROPERTIES OF MEDICINAL PLANTS: A REVIEW OF PLANTS WITH HYPOLIPIDEMIC, HEMOSTATIC, FIBRINOLYTIC AND ANTICOAGULANT EFFECTS (PART 1)
ABSTRACT The recent studies showed that many plants possessed cardiovascular effects. This review was designed to cover the hypolipidemic, fibrinolytic anti platelet aggregating and antioxidant effects of the med...