SOLUBILITY ENHANCEMENT OF POORLY SOLUBLE DRUG GLIMEPIRIDE BY SOLID DISPERSION TECHNIQUE
Journal Title: Int J of Pharm Rev& Res - Year 2016, Vol 6, Issue 1
Abstract
ABSTRACT Solid dispersion is the most widely used and accepted technique for improving the solubility of poorly soluble drugs. It is basically a drug-carrier two component system. Glimepiride is an anti-diabetic drug which is poor soluble and the attempt was made to enhance the solubility by using solid dispersion technique and the carriers used were hydroxypropyl methylcellulose (HPMC) and sodium starch glycolate (SSG).The glimepiride were formulated as solid dispersion with the carriers and evaluated. The drug release using SSG was found to be high than that of the plain drug and the formulation with HPMC. Key words: Solid dispersion, Dissolution rate, Bioavailability, Solubilization, Glimepiride, Carrier.
Authors and Affiliations
Valarmathi S*, Senthil Kumar M, Sujinidevi V, Nachammai V, Dhanalakshmi J
Keywords
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