SOLUBILITY ENHANCEMENT OF POORLY SOLUBLE DRUG GLIMEPIRIDE BY SOLID DISPERSION TECHNIQUE
Journal Title: Int J of Pharm Rev& Res - Year 2016, Vol 6, Issue 1
Abstract
ABSTRACT Solid dispersion is the most widely used and accepted technique for improving the solubility of poorly soluble drugs. It is basically a drug-carrier two component system. Glimepiride is an anti-diabetic drug which is poor soluble and the attempt was made to enhance the solubility by using solid dispersion technique and the carriers used were hydroxypropyl methylcellulose (HPMC) and sodium starch glycolate (SSG).The glimepiride were formulated as solid dispersion with the carriers and evaluated. The drug release using SSG was found to be high than that of the plain drug and the formulation with HPMC. Key words: Solid dispersion, Dissolution rate, Bioavailability, Solubilization, Glimepiride, Carrier.
Authors and Affiliations
Valarmathi S*, Senthil Kumar M, Sujinidevi V, Nachammai V, Dhanalakshmi J
Keywords
Related Articles
- EP ID EP90764
- DOI -
- Views 177
- Downloads 0
AN UPDATED REVIEW ON ANTI-ARTHRITIC MEDICINAL PLANTS
Arthritis is a chronic, inflammatory, systemic autoimmune disease characterized by pain, swelling and stiffness. Allopathic medications have been prescribed to alleviate symptoms of this disease which results into associ...
NANOSUSPENSIONS TECHNOLOGY IN DRUG DELIVERY – A REVIEW
Nanosuspensions is colloidal dispersions of nanosized drug particles stabilized by surfactants. They can also be defined as a biphasic system consisting of pure drug particles dispersed in an aqueous vehicle in which the...
A REVIEW OF STUDIES PERFORMED TO ASSESS PESTICIDE POLLUTION BY EARTHWORM’S GROWTH
Pesticides use affects the human health, soil ecosystems and atmosphere vicinity. It is possible to find examples where pesticides have impacted on soil non-target organisms mainly soil invertebrates. Earthworms play a i...
GENOME: WIDE APPROCHES FOR DEVELOPMENT OF VACCINES
The outcome of drug therapy is often unpredictable, ranging from beneficial effect to lack of efficacy to serious adverse effects. The improved understanding of the human immune system and the genetic make-up of pathogen...