SPECTROPHOTOMETRIC ESTIMATION OF DRUGS USING N-BROMO SUCCINAMIDE AND AMARNTH DYE COUPLE
Journal Title: Int J of Pharm Res & Analy - Year 2014, Vol 4, Issue 1
Abstract
Simple, specific, accurate and precise UV–visible spectrophotometric methods have been developed for the estimation of five drugs viz., Dobutamine hydrochloride, Duloxetine hydrochloride, Ondansetron hydrochloride, Sumatriptan succinate and Verapamil hydrochloride. These methods involve the addition of a known excess of NBS to the drugs in acid medium followed by estimation of residual NBS by reacting with a fixed amount of Amaranth and measuring the absorbance at 520nm. The proposed methods were found to be successful for the estimation of these drugs in bulk and their formulations. The results of analysis have been validated statistically for linearity, accuracy, precision, LOD and LOQ. Keywords: UV-visible spectrophotometry, Validation, Amaranth, Dobutamine HCl, Duloxetine HCl, Ondansetron HCl, Sumatriptan succinate, Verapamil HCl.
Authors and Affiliations
Prashanthi M , Venkateshwarlu G
Keywords
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