The Gastroprotective Effect of Coenzyme Q10 in IndomethacinInduced Gastropathy: Role of MMP-9
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2015, Vol 5, Issue 3
Abstract
Background : Coenzyme Q10 (CoQ10) is a vitamin-like substance with potent antioxidant activity. MMP-9 is one of the major proteins in the family of matrix metalloproteinases involved in extracellular matrix (ECM) remodeling . MMP-9 is modulated by oxidative stress and its activity was found to increase considerably in indomethacin-induced ulcers . Objective:To investigate whether CoQ10 gastroprotection against indomethacin induced gastric mucosal injury also involves modulation of MMP-9 activity.
Authors and Affiliations
Basmah A Hayder , Samir Y. N. Matloub
Keywords
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