Neutrophil-lymphocyte Ratio and Serum Ferritin, Folate, Vitamin B12 and 25-hydroxyvitamin D Levels in Children and Adolescents with Primary Headaches
Journal Title: Meandros Medical and Dental Journal - Year 2021, Vol 22, Issue 2
Abstract
Objective: Headache is one of the most common complaints in general pediatric outpatient clinics. We aimed to investigate the complete blood count (CBC) parameters and serum levels of 25-hydroxyvitamin D [25(OH)D], ferritin, vitamin B12 and folic acid in children and adolescents with primary headaches. Materials and Methods: In this study, 149 patients with primary headache [migraine, tension-type headaches (TTH) and unclassified headache] and 104 healthy controls, aged 5 to 18 years, were evaluated retrospectively. Age, gender, physical examination findings and laboratory parameters [CBC, 25(OH)D, vitamin B12, folic acid and ferritin] were also recorded for both groups. Results: The headache types in the primary headache group were TTH (48.1%), migraine (28.2%) and unclassified headache (23.7%). The primary headache group had lower median levels of ferritin and serum vitamin B12 than healthy controls (p=0.028 and p=0.014, respectively). The neutrophil-lymphocyte ratio (NLR) was significantly higher in the primary headache group (p=0.033). A binary logistic regression analysis model showed low ferritin levels as an independent risk factor for primary headaches (odds ratio =1.018, 95% confidence interval =1.003-1.032). Conclusion: The study results demonstrated lower serum vitamin B12 and ferritin and a higher NLR in children with primary headaches when compared to healthy children. We suggest that these findings require support from larger prospective studies.
Authors and Affiliations
Elif Çelik, Ayşe Anık, Müge Ayanoğlu
Keywords
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- EP ID EP694420
- DOI 10.4274/meandros.galenos.2021.26023
- Views 92
- Downloads 0
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