NSAID-enterotoxicity: focus on the problem
Journal Title: Сучасна гастроентерологія - Year 2018, Vol 0, Issue 5
Abstract
The nonsteroidal anti-inflammatory drugs (NSAIDs) are the most commonly prescribed medicines in the world. They are almost indispensable for quick elimination of pain, inflammation, and hyperthermia, but unfortunately, they have significant side effects, including related to the gastrointestinal tract. NSAID-induced gastropathy is well-studied and can be effectively overcome with acid-lowering drugs. NSAID-induced enteropathy and colonopathy, unfortunately, are less studied due to the complexity of the diagnosis. The gastrointestinal damages in the departments lower than Traits’ ligament account for about 40 % of all NSAID-induced gastrointestinal lesions, mostly often they are asymptomatic, but often become the cause of complications, including the life-threatening ones. Still, there are no effective medications for their treatment or prevention. This article presents a modern view of the pathogenesis of this condition, its epidemiology, and its clinical manifestations, as well as an overview of the available options for diagnostics, treatment and prevention of NSAIDs-induced entero- and colonopathy.
Authors and Affiliations
O. Ju. Gubska, A. A. Kuzminets
Keywords
Related Articles
- EP ID EP418330
- DOI 10.30978/MG-2018-5-50
- Views 112
- Downloads 0
Drug-induced liver damage in the onco-hematology patients: the assessment of the efficacy of sublingual ademetionine formulation
The authors presented the modern views on the mechanism of development, risk factors and treatment of the drug-inducedchronic hepatitis. The analysis has been performed for the efficacy of sublingual ademetionine formula...
NSAID induced gastropathy in the practice of a family doctor
Nonsteroidal anti-inflammatory drugs (NSAID) are the mostly often prescribed agent for the treatment of various pathologies. However their application associated with the development of side effects, and NSAID induced ga...
The new opportunities of treatment of non-alcoholic steatohepatitis
Objective — to evaluate the efficacy and safety of the dietary supplement Schisandrin®, 250 mg tablets (manufacturer Pharmacom Ltd.) in patients with non-alcoholic steatohepatitis. Materials and methods. The investigatio...
First experience of the study of prevalence of the Helicobacter pylori-negative peptic ulcer in Lviv Region
The prevalence of Helicobacter pylori-negative peptic ulcers of the stomach and duodenum in Ukraine has not been studied yet. The lack of accounting for such patients, lack of knowledge of risk factors for the developmen...
A clinical case of eosinophilic esophagitis combined with macroamylasemia
Eosinophilic esophagitis is one of the most prevalent esophageal diseases and the leading cause of dysphagia and food impaction in children and young adults. The authors presented a clinical case of a patient with eosino...