Ω-3 PUFA supplementation decreases nuclear factor κB activity and attenuates pressure overload-induced cardiac dysfunction
Journal Title: Postępy Nauk Medycznych - Year 2015, Vol 28, Issue 6
Abstract
Introduction. Supplementation with ω-3 polyunsaturated fatty acids (ω-3 PUFA) exerts cardioprotective effects in heart failure patients, however the mechanism is not well know. The present study assessed the effect of DHA+EPA on the activation of nuclear factor (NF)-κB and on the left ventricular (LV) response to pressure overload.Aim. The present study assessed the effect of DHA+EPA on the activation of nuclear factor (NF)-κB and on the left ventricular (LV) response to pressure overload.Material and methods. Male Wistar rats were fed a standard chow or DHA+EPA supplemented diet. After 1 week rats underwent abdominal aortic banding or sham surgery (n = 6-7/group). LV function was assessed by echocardiography after 12 weeks. In addition, we studied the effect of ω-3 PUFA on the cardiac NF-κB activity and expression of NF-κB target genes.Results. Male Wistar rats were fed a standard chow or DHA+EPA supplemented diet. After 1 week rats underwent abdominal aortic banding or sham surgery (n = 6-7/group). On the standard diet, 12 weeks of pressure overload induced significant LV hypertrophy, remodeling and contractile dysfunction, and increased cardiac (NF)-κB activity. Dietary DHA+EPA attenuated pressure overload induced cardiac pathology and inhibited (NF)-κB activity. DHA+EPA decreased mRNA expression of NF-κB-depended genes encoding proteins involved in regulation of inflammation (TNFα and IL-1β), apoptosis (Bcl2), and fibrosis (TGF-β1).Conclusions. Dietary supplementation with DHA+EPA attenuated pressure overload induced LV hypertrophy, remodeling and contractile dysfunction, which was associated with decreased cardiac (NF)-κB activity and switched expression of NF-κB target genes.
Authors and Affiliations
Monika K. Duda, Paweł Dobrzyń, Urszula Mackiewicz, Agnieszka Dobrzyń, Michał Mączewski
Keywords
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