OPTIMIZATION AND CHARACTERIZATION OF STAVUDINE CONTROLLED RELEASE TABLETS
Journal Title: Mintage journal of pharmaceutical and medical sciences - Year 2017, Vol 6, Issue 6
Abstract
Objective: The objective of the study is to develop controlled release tablets of stavudine. Methods: Wet granulation technique was adopted for the preparation of all these formulations. The developed tablets were evaluated for pre compression parameters; post compression parameters, in vitro dissolution study. Fourier Transform Infrared Spectroscopy (FTIR) study was used to know compatibility studies of formulations. The in vitro release kinetics were analyzed for different batches by different pharmacokinetic models such as zero order, first order, Higuchi, Korsmeyer-Peppas and Hixson-Crowell model. Results: Among all the developed batches F6 showed highest drug release 96.31% at the end of 13 h. The optimized formulation was found to be stable up to 3 months when tested for stability study at 40±2ºC/ 75±5% RH. Conclusion: It is concluded that dissolution profile of stavudine is more in F6 batch showing prolonged release of drug with highest concentration of polymer.
Authors and Affiliations
chinmaya keshari sahoo, asampally pavithra, muvvala sudhakar, satyabrata bhanja
Keywords
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