Optimized vascular network by stereolithography for tissue engineered skin

Journal Title: International Journal of Bioprinting - Year 2018, Vol 4, Issue 2

Abstract

This paper demonstrates the essential and efficient methods to design, and fabricate optimal vascular network for tissue engineering structures based on their physiological conditions. Comprehensive physiological requirements in both micro and macro scales were considered in developing the optimisation design for complex vascular vessels. The optimised design was then manufactured by stereolithography process using materials that are biocompatible, elastic and surface bio-coatable. The materials are self-developed photocurable resin consist of BPA-ethoxylated-diacrylate, lauryl acrylate and isobornylacrylate with Irgacure® 184, the photoinitiator. The optimised vascular vessel offers many advantages: 1) it provides the maximum nutrient supply; 2) it minimises the recirculation areas and 3) it allows the wall shear stress on the vessel in a healthy range. The stereolithography manufactured vascular vessels were then embedded in the hydrogel seeded with cells. The results of in vitro studies show that the optimised vascular network has the lowest cell death rate compared with a pure hydrogel scaffold and a hydrogel scaffold embedded within a single tube in day seven. Consequently, these design and manufacture routes were shown to be viable for exploring and developing a high range complex and specialised artificial vascular networks.

Authors and Affiliations

Xiaoxiao Han, Julien Courseaus, Jamel Khamassi, Nadine Nottrodt, Sascha Engelhardt, Frank Jacobsen, Claas Bierwisch, Wolfdietrich Meyer, Torsten Walter, Jürgen Weisser, Raimund Jaeger, Richard Bibb, Russell Harris

Keywords

Related Articles

Bioprinting of Multimaterials with Computer-aided Design/Computer-aided Manufacturing

Multimaterials deposition, a distinct advantage in bioprinting, overcomes material’s limitation in hydrogel-based bioprinting. Multimaterials are deposited in a build/support configuration to improve the structural integ...

Preparation and printability of ultrashort self-assembling peptide nanoparticles

Nanoparticles (NPs) have left their mark on the field of bioengineering. Fabricated from metallic, magnetic, and metal oxide materials, their applications include drug delivery, bioimaging, and cell labeling. However, as...

Three-dimensional-printing for microfluidics or the other way around?

As microfluidic devices are designed to tackle more intricate tasks, the architecture of microfluidic devices becomes more complex, and more sophisticated fabrication techniques are in demand. Therefore, it is sensible t...

A multi-scale porous scaffold fabricated by a combined additive manufacturing and chemical etching process for bone tissue engineering

It is critical to develop a fabrication technology for precisely controlling an interconnected porous structure of scaffolds to mimic the native bone microenvironment. In this work, a novel combined process of additive m...

In vitro pre-vascularization strategies for tissue engineered constructs–Bioprinting and others

Tissue-engineered products commercially available today have been limited to thin avascular tissue such as skin and cartilage. The fabrication of thicker, more complex tissue still eludes scientists today. One reason for...

Download PDF file
  • EP ID EP678688
  • DOI -
  • Views 160
  • Downloads 0

How To Cite

Xiaoxiao Han, Julien Courseaus, Jamel Khamassi, Nadine Nottrodt, Sascha Engelhardt, Frank Jacobsen, Claas Bierwisch, Wolfdietrich Meyer, Torsten Walter, Jürgen Weisser, Raimund Jaeger, Richard Bibb, Russell Harris (2018). Optimized vascular network by stereolithography for tissue engineered skin. International Journal of Bioprinting, 4(2), -. https://europub.co.uk/articles/-A-678688