Oxidative Stress: A Possible Mechanism of Atazanavir/Ritonavir Induced Renal Toxicity
Journal Title: International Journal of Contemporary Medical Research - Year 2016, Vol 3, Issue 1
Abstract
Introduction: Atazavavir/ritonavir (ATV/r) renal toxicity may be associatedwith oxidative stress because oxidative stress has been implicated in drugs induced renal toxicity. This study therefore evaluated the effect of ATV/r on renal function parameters and kidney oxidative stress markers of male albino rats. Materials and Methods: Adult male albino rats were orally treated with 150/50 mg/kg of ATV/r for 1-4 weeks and (15/5 - 120/40) mg/kg of ATV/r for 8 weeks. Animals were sacrificed at the end of treatment, blood sample was collected and serum extracted and evaluated forserum creatinine, urea, and uric acid levels. Kidneys were collected weighed and evaluated for glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione-s-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPX) and malondialdehyde (MDA). Results:Treatment with ATV/r did not produce any significant (p>0.05) effect on absolute kidney weight when compared to the control. Significant (p<0.05) dose and time-dependent increases in serum creatinine, urea and uric acid levels were observed with ATV/r treatment when compared to the control. Also, significant (p<0.05) dose and time-dependent decreases in kidney SOD,CAT, GST, GSH, GR, and GPXlevels with increases in MDA levels occurred with ATV/r treatment when compared to the control. Conclusion: Observationin this study shows ATV/r induced renal toxicity is time and dose-dependent and may be dueto oxidative stress.
Authors and Affiliations
Elias Adikwu, Igbans Rejoice Obele, Apiakase Williams
Keywords
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