Peculiarities of the clinical course and visceral adipose tissue in patients with non-alcoholic fatty liver disease against the background of metabolic syndrome
Journal Title: Сучасна гастроентерологія - Year 2018, Vol 0, Issue 2
Abstract
Objective — to study the peculiarities of metabolic disturbances in patients with nonalcoholic fatty liver disease (NAFLD) and their role in the development and progression of liver steatosis. Materials and methods. Investigation involved 62 patients with NAFLD: 26 men (40 %) and 36 women (60 %). The mean age of patients was (57.34 ± 9.2) years. The control group consisted of age and gender matched 20 healthy donors. All patients were undergone physical and instrumental examination in accordance with the current order of the MOH of Ukraine N 826 of 06.11.2014. In addition to the standard survey, the body composition of patients was monitored with the use of OMRON BF-511 electronic instrument (Japan, 2011), and the visceral adiposity index (VAI) was calculated by the method of Amato MC (2010) to determine visceral adipose tissue dysfunction (VAT). Results. The clinical symptomatology in patients with NAFLD against the background of the metabolic syndrome was defined as a lowsymptom type, which did not correlate with the significant changes in the indices of laboratory and instrumental examinations. Among NAFLD patients, the vast majority of patients have had metabolic disorders in the form of type 2 diabetes mellitus (45 %), hypertension (28 %), overweight and obesity (74 %). The VAT rates were elevated in all patients. The VAI parameters in NAFLD patients were higher than in subjects with liver steatosis (p < 0.05). Conclusions. The significant increase in the percentage of visceral adipose tissue and the degree of its activity in patients with NAFLD, regardless of the body mass index, suggested the pathogenetic role of visceral obesity in the development of metabolic changes in this category of patients.
Authors and Affiliations
G. D. Fadieienko, I. E. Kushnir, V. M. Chernova, Т. А. Solomentseva, Ya. V. Nikiforova
Keywords
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