Pharmacogenomics for Obesity Associated Diabetes: A Review
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2010, Vol 2, Issue 5
Abstract
This review aims at exploring new pharmacogenomics for obesity associated diabetes. The recent advances in pharmacogenomic therapy lead to the gene discovery of various diseases. In this regard we summaries the various genes which are supposed to be involved in occurrence of obesity associated diabetes. Such genes include Interlukin 6 , Insulin receptor substrate - 2, Protein Tyrosine Phosphatase 1B, Adiponectin Gene, Islet Amyloid Polypeptide, Ectonucleotide Pyrophosphatase/phosphodiesterase 1 gene, Uncoupling protein, Resistin, Lamins A and C, Leptin Receptor Gene etc. These genes are considered to be responsible for the pathophysiology of obesity associated diabetes and can be used as targeted therapy, paves the way for development of new pharmacogenomic therapy. To list a few, PPAR γ agonists, PPAR γ and RXR agonists, PPAR γ and PPARδ agonists, direct modulators of metabolism, PPAR α & PPAR γ agonists, canabinoid-1 antagonist, ciliary neurotropic factors and selective β-3 adrenergic agonists are the pharmacogenomic therapies used in current practice towards the additional advantages. To conclude, pharmacogenomic therapy will provide an added advantage over the currently available conventional therapies and this study will be helpful for future studies towards inventions in pharmacogenomic therapies for obesity associated diabetes.
Authors and Affiliations
Manoj N. Patil , Virendra G. Kagathara , Uday N. Harle , Timir B. Patel , Roshni P. Solanki , Khushbu R. Chauhan , Rohini R. Pujari
Pharmacological studies of anti-diarrhoeal activity of Guettarda speciosa (L.)in experimental animals.
Aims: The purpose of the present study was to evaluate scientifically the anti-diarrhoeal effects of ethanolic (90%) extract of inner bark of Guettarda speciosa. Linn (EEGS) was studied against castor oil-induced-diarrho...
Analytical Method Development and Validation for Pre-Clinical Analysis
Pre-clinical phase is a laboratory test of a new drug on animal subjects, conducted together evidence justifying a clinical trial. For those drugs which are in clinical phase, method development requires ...
Formulation and Evaluation of Taste Masked Orodispersible Tablets of Ondansetron Hydrochloride
The demand for mouth dissolving tablets has been growing, during the last decade especially for geriatric and pediatric patients because of swallowing difficulties. The purpose of this research was to mask the...
EFFECT OF HPMC 4 CPS AND CARBOPOL 974P NF ON RELEASE KINETICS OF<br /> CIPROFLOXACIN FROM KOLLIDON® SR EMBEDDED MATRIX TABLETS
Controlled release (CR) Ciprofloxacin (CFX) matrix tablets were prepared using Ciprofloxacin betaine as a model drug and Kollidon® SR as a core matrix former. Kollidon® SR embedded CFX matrix tablets were then...
Moringa oleifera: a natural gift-A review
Moringa oleifera, Lam {Syn M.pterygosperma Gaertn} usually mentioned in literature as Moringa, is a natural as well as cultivated variety of the genus Moringa belonging to family Moringaceae .It is one of the riches...