Pharmacological studies of anti-diarrhoeal activity of Guettarda speciosa (L.)in experimental animals.
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2009, Vol 1, Issue 2
Abstract
Aims: The purpose of the present study was to evaluate scientifically the anti-diarrhoeal effects of ethanolic (90%) extract of inner bark of Guettarda speciosa. Linn (EEGS) was studied against castor oil-induced-diarrhoea model in rats. Methods: Antidiarrhoeal activity of 90% ethanol extract of Guettarda speciosa was investigated in this study using castor oil-induced-diarrhoea, enteropooling and Small intestinal transit models in rats. The weight and volume of intestinal content induced by castor oil were studied by enteropooling method. Results: Standard drug diphenoxylate (5 ml/kg, p.o) was significant reductions in fecal output and frequency of droppings whereas EEGS at the doses of 200 and 400 mg/kg p.o significantly (P<0.001) reduced the castor-oil induced frequency and consistency of diarrhoea and enteropooling. The gastrointestinal transit rate was expressed as the percentage of the longest distance travelled by the charcoal divided by the total length of the small intestine. EEGS at the doses of 200 and 400 mg/kg significantly inhibited (P<0.001) the castor oil induced charcoal meal transit. Conclusion: The EEGS showed marked reduction in the number of diarrhoea stools and the reduction in the weight and volume of the intestinal contents, as well as a modest reduction in intestinal transit. The results obtained establish the efficacy and substantiate the folklore claim as an anti- diarrheal agent. Further studies are needed to completely understand the mechanism of anti-diarrhoeal action of Guettarda speciosa.
Authors and Affiliations
Gandhimathi R, Saravana Kumar A, Senthil Kumar K. K, Kusuma Praveen Kumar , Uma Maheswari J
Keywords
Related Articles
- EP ID EP102360
- DOI -
- Views 117
- Downloads 0
Evaluation of antibacterial and antioxidant activity of Mangifera indica (leaves)
The genus Mangifera indica belongs to the family Anacardiaceae and comprises of 40 species distributed in tropical and sub-tropical parts of South East Asia, Africa and Latin America The resin is useful in cutaneous dise...
Microencapsulation: A vital technique in novel drug delivery system
Novel drug delivery systems have several advantages over conventional multi dose therapy. Much research effort in developing novel drug delivery system has been focused on controlled release and sustained rele...
Studies on Formulation and optimization of Gastro Retentive multiParticulates of Glibenclamide and Metformin hydrochloride for the treatment of Type II Diabetes mellitus using Gelucire: A Review.
In order to increase the bioavailability of poorly soluble drug as well as highly soluble drug, the residence time of the orally administered dosage form in the upper GIT needs to be prolonged. Gelucire are used as carr...
Microbial production and osmac study of Streptomyces species coded as G-16
The previously isolated Streptomyces species coded as G16 was used in the present study. The test media selected were starch casein broth (SCB), GMYP broth and Soya been meal broth (SOB). The seed inoculums were transfer...
Development and Physiochemical, In-Vitro Evaluation of Antihypertensive Transdermal
Transdermal patches of Losartan with hydrophilic and hydrophobic polymers containing the drug reservoir were prepared by solvent evaporation method. In this experiment, the membranes of ethylcellose and eudragit RS...