Phosphatidylinositol 4-Kinase Enzymes: Functional Roles and Potential for Drug Target
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 1
Abstract
The two types of phosphatidylinositol 4-kinases (PI-4Ks) synthesize phosphatidylinositol 4-phosphate (PI-4P), a member of the phosphoinositide family. Phosphoinositides (PIPs) are synthesized from phosphatidylinositol (PI), a lipid containing the myo-inositol head group. PI can be phosphorylated at positions 3, 4, and 5 of the inositol ring which allows for seven different PIPs. Indeed, all of these enzymes have been identified in the cell. For instance, one prominent function of PIPs is to serve as membrane markers typically in concert with organelle specific proteins. PI(4,5)P2 is the main lipid determinant of the plasma membrane and PI3P and PI(3,5)P2 of the early and late endosomes. PI-4P is the main lipid determinant of the Golgi and trans-Golgi network (TGN) but, additionally, helps to define the specific character of the plasma membrane. This article reviews the recent developments in research on these enzymes and their potential for drug target.
Authors and Affiliations
Manoj G Tyagi, Deepasree Sukumaran, Saibal Das,, Vishakha Tyagi, Pulastya A Vora
Keywords
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- EP ID EP388201
- DOI 10.9790/3008-1201025053
- Views 61
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