Phospho-onco-proteomics
Journal Title: International Journal of Genetics - Year 2009, Vol 1, Issue 1
Abstract
Phosphoproteomics is the global analysis of protein phosphorylation, holds great promise for the discovery of cell signaling events that link changes in dynamics of protein phosphorylation to the progression of various diseases, particularly cancer and diabetes. Proteomic research first came for research with the introduction of two-dimensional gel electrophoresis. Proteomics has been increasingly applied to oncology research with the widespread introduction of mass spectrometry and protein-chip. Applying proteomics to foster an improved understanding of cancer pathogenesis develop new tumor biomarkers for diagnosis, and early detection using proteomic portrait of samples. The study of Phospho-onco-proteomics provides a better understanding of cancer diagnosis.
Authors and Affiliations
V. S. Gomase, Shyamkumar Krishnan
Keywords
Related Articles
- EP ID EP170143
- DOI 10.9735/0975-2862.1.1.6-15
- Views 60
- Downloads 0
MOLECULAR CHARACTERIZATION OF GROWTH HORMONE RELEASING HORMONE RECEPTOR (GHRHR): CLONING, TISSUE DISTRIBUTION, EXPRESSION ANALYSIS AND HOMOLOGY MODELING IN FARMED CARP, Labeo rohita
Growth hormone releasing hormone receptor (GHRHR) is a trans-membrane receptor belonging to the Class-II GPCR family. GHRHR activates growth-hormone production consequent upon triggering somatotroph proliferation. Unlike...
ADRA2A IS A CYSTIC FIBROSIS MODIFIER GENE
Background: Cystic fibrosis (CF) is an autosomal disease with characteristics of a complex disease. Understanding ADRA2A polymorphisms are important to elucidate clinical variability that is encountered in inflammatory d...
Proteins bioassay: recent scenario for new target validations
This article reviews different aspects of protein engineering technologies such as protein screening, NMR, EM & x-ray crystallography, In silico protein structure, protein cell free technologies, protein chips and arrays...
MOLECULAR GENETICS OF NON-SYNDROMIC CLEFTS REVISITED
Cleft of the lip and palate (CL/P) are generally divided in to two groups, isolated cleft palate and cleft with or without cleft palate representing a heterogeneous group of disorders affecting the upper lip and the roof...
DETECTION OF DNA DAMAGE IN OBESE CARDIOVASCULAR DISEASE PATIENTS AND COMPARISON BETWEEN GENDERS: A CASE-CONTROL STUDY
Background- Obesity and cardiovascular disease (CVD) with the increased stress/ inflammation may cause DNA damage posing risk for malignancy hence assessment of DNA damage gains importance as a pre-cancerous biomarker. M...