PHYTOCHEMICAL COMPOSITION, BIOACTIVITY AND WOUND HEALING POTENTIAL OF EUPHORBIA HETEROPHYLLA (Euphorbiaceae) LEAF EXTRACT
Journal Title: International Journal of Pharmaceutical and Biological Research - Year 2010, Vol 1, Issue 2
Abstract
Villagers have traditionally used E.heterophylla parts to treat a variety of ailments. The objective of this study was to evaluate the phytoconstituents, bioactivity and wound healing potential of E.heterophylla leaf extracts in experimental Rattus novergicus.All experiments were conducted following standard procedures. The order of decreasing concentrations of the Phytochemical is alkaloids>cyanide >tannins>flavonoids> saponins. The order of decreasing cytotoxicity is aqueous extract (fresh)> ethanol extract (fresh)> ethanol extract (dry)> aqueous extract (dry). The extracts in the form of an ointment was used for evaluating the wound-healing potential in an excision wound model. The wound-healing property observed in E.heterophylla is attributed to the phytoconstituents and the faster process of wound-healing could be a function of either the individual or additive effects of the phytoconstituents.The ethanol extracts exhibited high percentage of wound closure. The prophylactic effect elicited by the extracts in terms of wound contraction and related biochemical parameter strongly support the healing and sealing characteristics of E.heterophylla leaf gel in rats following topical administration.
Authors and Affiliations
Omale James* , Emmanuel . T. Friday
Keywords
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