PHYTOSOMES: NOVEL APPROACH FOR DELIVERING HERBAL EXTRACT WITH IMPROVED BIOAVAILABILITY
Journal Title: Pharma Science Monitor-An International Journal Pharmaceutical Sciences - Year 2011, Vol 2, Issue 1
Abstract
Plant-derived polyphenols are increasingly gaining attention as dietary supplements for their multidimensional role in homeostatic management of inflammation, to support detoxication, and for anticancer, weight loss, and many other benefits. Many plants extracts rich in flavonoids and polyphenolics have been extensively explored for their pro-homeostatic effects on genes, transcription factors, enzymes, and cell signaling pathways, but the poor bioavailability of some polyphenols likely contributes to poor clinical trial outcomes. Bioavailability of flavonoids, both in aglyconic or glycosidic form, is reported to be low and erratic due to limited absorption, elevated presystemic metabolism and rapid elimination. The phytosome technology creates intermolecular bonding between individual polyphenol molecules and one or more molecules of the phospholipids, phosphatidylcholine (PC). A Phytosome is generally more bioavailable than a simple herbal extract due to its enhanced capacity to cross the lipid-rich biomembranes and reach circulation. As a molecular delivery vehicle, phytosome technology substantially enhanced the bioavailability of many popular herbal extracts including milk thistle, Ginkgo biloba, grape seed, green tea, hawthorn, ginseng etc and can be further developed for clinical applicability of polyphenols and other poorly absorbed phytoconstituents. This article reviews the recent advances and applications of various standardized herbal extract phytosomes as a tool of drug delivery.
Authors and Affiliations
N. S. Acharya , G. V. Parihar , S. R. Acharya
Keywords
Related Articles
- EP ID EP145148
- DOI -
- Views 140
- Downloads 0
APPLICATION OF ACUPUNCTURE THERAPY IN TYPE 2 DIABETES MELLITUS PATIENTS
SIMULTANEOUS ESTIMATION OF NEBIVOLOL HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE IN BULK AND IN A TABLET DOSAGE FORM BY MULTICOMPONENT AND SIMULTANEOUS ESTIMATION METHOD
Novel, simple, sensitive, rapid, accurate and economical spectrophotometric methods have been developed for simultaneous estimation of Nebivolol Hydrochloride and Hydrochlorothiazide. These methods involve solving of s...
RP- HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF LOSARTAN POTASSIUM AND ATENOLOL IN TABLET FORMULATION
This work is concerned with application of simple, precise, accurate and reproducible reverse phase high performance liquid chromatographic (RP-HPLC) method for simultaneous estimation of Losartan potassium (LP) and At...
A SYSTEMATIC REVIEW ON NATURAL MEDICINE USED FOR THERAPY OF DIABETES MELLITUS OF SOME INDIAN MEDICINAL PLANTS
Diabetes mellitus is one of the world’s major diseases. It currently affects an estimated 143 million people worldwide and the number is growing rapidly. In the India, about 1- 5% population suffer from diabetes or rel...
PHARMACOGNOSTIC STUDIES OF THE SEED OF SYZYGIUM<br /> CUMINI LINN
Jamun is a very common, large evergreen beautiful tree of Indian subcontinent. The scientific name of Jamun is Eugenia jambolana Lam or Syzygium cumini Linn belongs to the family myrtaceae. The seed of Syzygium cumini...