POWDER FLOWABILITY AS A FUNCTIONALITY PARAMETER OF THE EXCIPIENT GALENIQ 720
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 9
Abstract
Objective: The purpose of the work was the assessment of the GalenIQ 720 flowability as a functionality parameter of the excipient, comparing two different methods.Methods: The evaluated parameters were the powder flow through different size orifices and the compressibility index, as absolute values and as values relative to Helmcel 200. The parameters determined with pure excipients and in mixtures with a model drug, metronidazole. Results: The compressibility index is a specific measurement for each powders blend that allows the assessment of its overall flow properties. Flowability, expressed as the flow rate, shows so many different results as orifices are being tested. Both methods exhibit comparable results only by wide orifice sizes where the interaction with de orifice walls is minimized. The flow rate increases progressively, mostly in a potential relationship, with an increasing orifice diameter. The flow rate of GalenIQ 720 attains a maximum with 0.4-0.8% magnesium stearate. Formulations containing GalenIQ 720 show about 2.8 times greater flowability than those containing Helmcel 200 while the flowability of GalenIQ 720 is about 8.7 times greater than that of Helmcel. The presence of metronidazole attenuates the differences observed by the flowability of pure excipients and its spread.Conclusion: Both methods consistently show a comparable improvement of metronidazole flowability with GalenIQ 720 and a deterioration of the same with Helmcel 200. The knowledge of the individual materials flowability allows the inference of their effect on the flowability of their mixtures but not the magnitude of this effect.Â
Authors and Affiliations
Karina Ivonne Fuentes-gonzÃlez, Leopoldo Villafuerte-robles
Keywords
Related Articles
- EP ID EP579532
- DOI -
- Views 55
- Downloads 0
ANTIOXIDANT AND HEPATOPROTECTIVE EFFECTS OF JUSTICIA SPICIGERA ETHYL ACETATE FRACTION AND CHARACTERIZATION OF ITS ANTHOCYANIN CONTENT
Objective: The antioxidant and hepatoprotective activities of ethyl acetate (EA) fraction of the dried aerial part of Justicia spicigera were evaluated and the characterization of its anthocyanin content was done. Metho...
THE IMPROVEMENT OF BETULIN-3, 28-DIPHOSPHATE WATER-SOLUBILITY BY COMPLEXATION WITH AMINES–MEGLUMINE AND XYMEDON
Objective: To study betulin-3,28-diphosphate (BDP) water solubility improved by forming salt complexes with hydrophilic amino alcohols: meglumine as acidosis corrector and xymedon as the water-soluble antioxidant. Metho...
RECENT DEVELOPMENTS AND MULTIPLE BIOLOGICAL ACTIVITIES AVAILABLE WITH 1, 8-NAPHTHYRIDINE DERIVATIVES: A REVIEW
Within the wide range of nitrogen-containing heterocyclic compounds, the derivatives of 1,8-naphthyridine (NPTR) have gained a rising interest due to their reported versatile biological activities. The derivatives of NPT...
COST ANALYSIS OF EMERGENCY VISITS DUE TO DRUG RELATED PROBLEMS
Objective: To identify patients coming to Emergency Medicine Department (EMD) with drug related problems, classify the DRPs and calculate the direct cost spent for treating them. Methods: This was a prospective observat...
A RETROSPECTIVE STUDY: THE OFF-LABEL USE OF ANTICONVULSANTS AT A PRIVATE HOSPITAL IN INDONESIA
Objective: Anticonvulsant is one class of drugs often used off-label. This study was conducted to investigate the prevalence and the indication of the off-label use of anticonvulsants in a private hospital in Java, Indon...