Preclinical evaluation of anti-cancer effect of naringenin in 7, 12-dimethyl benzanthracene induced breast cancer in female rats
Journal Title: Medpulse International Journal of Pharmacology - Year 2018, Vol 8, Issue 2
Abstract
Background: The present study is aimed to screen the anti-cancer effect of naringenin in 7,12-dimethyl benzanthracene induced breast cancer in female Wistar albino rats. Methodology: The study was conducted in the Division of Pharmacology, Annamalai University, Tamil Nadu. Female Wistar Albino rats weighing 140-150gm were selected in this study. All the animals were kept in Central Animal House under standard conditions. Total 36 rats were divided into six groups, each of 6 rats. G-1 (Control), G-2- (7,12-Dimethyl benzanthracene (25mg/kg/BW/sc), G-3 (7,12-Dimethyl benzanthracene(25mg/kg/sc)+Vincristine(500µg/kg/BW/ip),G-4(7,12-Dimethylbenzanthracene(25 g/kg/sc)+Naringenin (50 mg/kg/BW/PO), G-5 (7,12-Dimethyl benzanthracene (25 mg/kg/sc)+Naringenin (100 mg/kg/BW/PO) and G-6 (7,12-Dimethyl benzanthracene (25 mg/kg/sc)+Naringenin (200 mg/kg/BW/PO). Inducing drug was administered only once. All the drugs were given upto 16 weeks. At the end of study period rats were sacrificed. The breast tissue was insolated and used for estimation of anti-oxidant enzymes like TBARS, Super oxide dismutase, Catalase, Glutathione and Glutathione peroxidase. Results: Group-2 showed significant changes compared to group-1. Group-3 and 5 showed significant difference compared to Group-2. Group-5 did not show significant difference compared to Group-3 in TBARS, super oxide disumutase, catalase, glutathione and glutathione peroxidase enzymes. Conclusion: Naringenin showed significant dose dependent anti-cancer effect in this study.
Authors and Affiliations
Sandeep V M, Nirmala P, Sarath Babu K
Keywords
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- EP ID EP471396
- DOI 10.26611/1010822
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