Preparation and Evaluation of Ethyl Cellulose Microspheres Containing Diclofenac Sodium by Novel W/O/O Emulsion Method
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2010, Vol 2, Issue 12
Abstract
The aim of present study was to formulate and evaluate microencapsulated controlled release preparations of a highly water/soluble drug, Diclofenac Sodium by (water in oil) in oil emulsion technique. Ethylcellulose, a biocompatible polymer is used as the retardant material. Various processing and formulation parameters such as drug/polymer ratio, volume and concentration of processing medium were optimized to maximize the entrapment efficiency. The release of DFS from ethyl cellulose microsphere was compared and possible release mechanism proposed by fitting in to different kinetic models. Microspheres were prepared by water in oil in oil emulsion technique using dichloromethane/ethanol solvent system. Span 80 was used as the dispersing agent and n-hexane was added to harden the microspheres. The prepared microspheres were characterized for their particle size and drug loading and drug release. The in-vitro release studies were carried out in phosphate buffer at pH 7.4. The prepared microspheres were white, free flowing and spherical in shape. The drug-loaded microspheres showed 51.2% of entrapment and release was extended up to 10 h. The in vitro drug release from the microspheres was affected by drug/polymer ratio. The best/fit release kinetics was achieved with Higuchi plot followed by zero order and first order. The release of DFS was influenced by altering the drug to polymer ratio and the drug release was found to be diffusion controlled.
Authors and Affiliations
Naveen Chella , Kiran Kumar Yada , Rashmi Vempati
Keywords
Related Articles
- EP ID EP113434
- DOI -
- Views 137
- Downloads 0
Antibacterial and Antifungal efficacy of steam distillate of<br /> Moringa oleifera Lam.
The present study describes antibacterial and antifungal activity of steam distillate of Moringa oleifera Lam, a pan-tropical species known for its nutritional and medicinal properties. A considerable reduction in the gr...
Stability-indicating High Performance Thin Layer Chromatographic Determination of Clozapine in Tablet Dosage Form
A simple, selective, precise and stability-indicating high-performance thin-layer chromatographic method of analysis of Clozapine in pharmaceutical dosage form was developed and validated. The method employed TLC alumini...
Synthesis of novel piperazine and morpholine linked substituted<br /> pyrimidine derivatives as antimicrobial agents
Several 6-(substituted)-5-cyano-2-thiouracils 1a-d, were prepared by the condensation of different aldehydes with ethylcyanoacetate and thiourea through a single step reaction by conventional and microwave irradiation te...
SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME 2, 4, 5 TRIPHENYL IMIDAZOLE DERIVATIVES
A series of 1-substituted 2, 4, 5 triphenyl imidazoles were synthesized by the reaction equimolar mixture of 2, 4, 5 triphenyl imidazole with chloro compound in the presence of anhydrous potassium carbonate. T...
Modulatory effect of NONI-Herbal formulation against ethylene glycol induced nephrolithiasis in albino rats.
The effect of NONI-herbal formulation against ethylene glycol induced nephrolithiasis in albino wistar rats is summarized in this study. Lithiasis was induced in rats by administering 0.75% ethylene glycol in&...