Preparation and Evaluation of Ethyl Cellulose Microspheres Containing Diclofenac Sodium by Novel W/O/O Emulsion Method
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2010, Vol 2, Issue 12
Abstract
The aim of present study was to formulate and evaluate microencapsulated controlled release preparations of a highly water/soluble drug, Diclofenac Sodium by (water in oil) in oil emulsion technique. Ethylcellulose, a biocompatible polymer is used as the retardant material. Various processing and formulation parameters such as drug/polymer ratio, volume and concentration of processing medium were optimized to maximize the entrapment efficiency. The release of DFS from ethyl cellulose microsphere was compared and possible release mechanism proposed by fitting in to different kinetic models. Microspheres were prepared by water in oil in oil emulsion technique using dichloromethane/ethanol solvent system. Span 80 was used as the dispersing agent and n-hexane was added to harden the microspheres. The prepared microspheres were characterized for their particle size and drug loading and drug release. The in-vitro release studies were carried out in phosphate buffer at pH 7.4. The prepared microspheres were white, free flowing and spherical in shape. The drug-loaded microspheres showed 51.2% of entrapment and release was extended up to 10 h. The in vitro drug release from the microspheres was affected by drug/polymer ratio. The best/fit release kinetics was achieved with Higuchi plot followed by zero order and first order. The release of DFS was influenced by altering the drug to polymer ratio and the drug release was found to be diffusion controlled.
Authors and Affiliations
Naveen Chella , Kiran Kumar Yada , Rashmi Vempati
Keywords
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