Prevalence of Enterococcal Infection and the Antimicrobial Susceptibility Profile of the Organism with Special Reference to Vancomycin: A Study in a Rural Medical College Hospital in Eastern India.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 1
Abstract
Enterococci, once regarded as commensal flora are emerging as pathogen for multiple human infections. Their intrinsic resistance and properties of quick acquisition of resistance towards many in use and reserve antimicrobials draws the problem statement for these bacteria. The study eyes to determine the prevalence of Enterococccal infections and their antimicrobial susceptibility pattern to create a database and formulate guidelines for the empirical treatment. A prospective study was done over a period of 12 months in a rural tertiary care hospital enrolling patients having features of infections. Various samples were collected depending on clinical syndromes following criteria of inclusion and exclusion. Culture of samples was done followed by identification of resultant organisms including Enterococcus spp. as per standard guidelines. Antimicrobial susceptibility testing done for Enterococci isolates only by conventional disc diffusion method following CLSI guideline. Vancomycin resistance was tested by disc diffusion and Vancomycin screen agar method. In one year period a total 350 samples were cultured from different clinical cases. 173 of them were culture positive and 34 samples yielded Enterococus spp. Enterococus faecalis and Enterococus faecium isolates were 32 and two in number respectively. The overall prevalence of Enterococci was 9.71%. All Enterococci isolates were susceptible to Vancomycin, Linezolid, Teicoplanin. E. Faecalis was still susceptible towards Nitrofurantoin (86.2%), and HL Gentamicin (68.75%), HL Streptomycin (56%) but to a lesser extent to Fluoroquinolones, Chloramphenicol (21.86%) and Ampicillin (31.25%). E. faecium isolates were resistant to Fluoroquinolones , Chloramphenicol , HL Streptomycin (100%) and were susceptible to Nitrofurantoin, and HL Gentamicin, Ampicillin (50%). Vancomycin resistance among Enterococci was not an emerging problem in this geographic area. Prevalence of Enterococcus faecalis was higher than Enterococcus faecium. Enterococcus faecium was more drug resistant than Enterococcus faecalis.
Authors and Affiliations
DR. Hirak Jyoti Raj, DR. Munmun Das (Sarkar), Dr. Subrangshu Mondal
Keywords
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- EP ID EP430902
- DOI 10.9790/0853-1801010915.
- Views 66
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