Research advances on epigenetic mechanism of anxiety disorders and related drug treatment
Journal Title: Journal of Air Force Medical University - Year 2023, Vol 44, Issue 4
Abstract
Anxiety disorders are common mental disorders characterized by excessive fear and anxiety and accompanied by abnormal gene regulation and synaptic dysfunction. The pathogenesis is complex. A large number of studies have confirmed that permanent changes of gene expression caused by epigenetic changes in related brain regions are important mechanisms for the occurrence of anxiety disorders. This paper reviews the research advances on epigenetic mechanisms including the roles of DNA methylation, histone modification and microRNA regulation in anxiety disorders, and discusses the anxiolytic effect and potential mechanism of histone deacetylase inhibitor in preclinical and clinical trials, so as to provide new ideas and directions for the study of epigenetic drug treatment of anxiety disorders.
Authors and Affiliations
LI Yujiao
Keywords
Related Articles
- EP ID EP727780
- DOI -
- Views 60
- Downloads 0
Epigenetic modification of tumor: a discussion based on re-recognition of kidney-storing-essence
The essence stored in the kidney includes innate essence and acquired essence. Based on the re-understanding of kidneyō€†³s function of storing the acquired essence, this paper combines epigenetic modification and tumor mi...
Design of a standardized positioning method for handheld detection probe of electrical impedance scanning of the breast
Objective To study a standardized positioning method for handheld detection probe of electrical impedance scanning (EIS) to reduce the difference of detection positions caused by manual operation of the probe in breast...
Incidence and risk factors of intraoperative hypothermia based on two different definitions in patients undergoing surgery for gastrointestinal tumors
Objective To investigate the incidence and risk factors of intraoperative hypothermia with two different definitions. Methods A total of 6 156 patients undergoing elective operation for gastrointestinal tumors from May...
Alterations of NR1 expression and phosphorylation in the medial prefrontal cortex during neuropathic pain accompanied by negative emotions
Objective To study alterations of the NR1 subunit of N-methyl-D-aspartate receptors (NMDARs) in the expression and phosphorylation in medial prefrontal cortex (mPFC) brain region under the condition of neuropathic pain...
Reexamination, analysis and correction of 1 288 cases with decreased platelet count
Objective To classify and identify the false-positive cases of decreased platelet (PLT) count in laboratory by means of blood smear review, and to explore relevant technical adjustment and correction, so as to provide m...