Research advances on epigenetic mechanism of anxiety disorders and related drug treatment
Journal Title: Journal of Air Force Medical University - Year 2023, Vol 44, Issue 4
Abstract
Anxiety disorders are common mental disorders characterized by excessive fear and anxiety and accompanied by abnormal gene regulation and synaptic dysfunction. The pathogenesis is complex. A large number of studies have confirmed that permanent changes of gene expression caused by epigenetic changes in related brain regions are important mechanisms for the occurrence of anxiety disorders. This paper reviews the research advances on epigenetic mechanisms including the roles of DNA methylation, histone modification and microRNA regulation in anxiety disorders, and discusses the anxiolytic effect and potential mechanism of histone deacetylase inhibitor in preclinical and clinical trials, so as to provide new ideas and directions for the study of epigenetic drug treatment of anxiety disorders.
Authors and Affiliations
LI Yujiao
Keywords
Related Articles
- EP ID EP727780
- DOI -
- Views 33
- Downloads 0
Injury classification and early treatment points of maxillofacial war wounds
As the change of the mode of modern war, the incidence of maxillofacial war wounds has gradually increased, which has ranked first in the Russia-Ukraine conflict. It is very important to recognize the characteristics of...
Analysis of pregnancy outcome of different cervical cerclage in the treatment of cervical insufficiency
Objective To study the clinical effect of different cervical cerclage on patients with cervical insufficiency (CI). Methods The clinical data of 527 patients diagnosed with CI and treated with different cervical cerclag...
Correlation between circadian rhythm type and intervertebral disc degeneration
Objective To clarify the correlation between intervertebral disc degeneration ( IDD) and circadian rhythm type, and determine whether circadian rhythm type is an independent risk factor for IDD. Methods A total of 238...
Design and development of “ Man-Machine System ” training system based on scaffolding teaching method
Objective To design and develop a training system for classroom teaching based on the advanced smart classroom hardware platform and scaffolding teaching method of Air Force Medical University, aiming at the teaching co...
Effect of hypoglycemia fear on anxiety in diabetic patients with hypoglycemia
Objective To explore the effect of hypoglycemia fear on anxiety in diabetic patients with hypoglycemia, and test the regulating effect of psychological resilience. Methods A total of 167 diabetic patients with hypoglyce...