Risk factors associated with severe coronavirus disease 2019 in maintenance hemodialysis patients
Journal Title: Chinese Journal of Clinical Research - Year 2024, Vol 37, Issue 1
Abstract
<b>Objective</b> To analyze the risk factors of severe coronavirus disease 2019 (COVID-19) in maintenance hemodialysis patients, and provide reference for early risk identification of the patients. <b>Methods</b> The clinical data of 73 maintenance hemodialysis patients diagnosed with COVID-19 admitted to Jilin Province Peoples Hospital from March to April 2022 were restrospectinely collected, and the patients were divided into MC group (mild and ordinary type, n=61) and SC group (severe and critically severe type, n=12) based on clinical classification. The patients baseline data ［age, gender, COVID-19 vaccination status, age adjusted Charlsons complication index (aCCI), primary hypertension, diabetes, coronary heart disease, malignant tumor, dialysis time］, first clinical symptoms (fever, dry cough, fatigue, sore throat, diarrhea, dyspnea) and laboratory examination indexes within 24 hours of admission (total number of white blood cells, neutrophils and lymphocytes; C-reactive protein, procalcitonin, D-dimer, albumin) were collected. Multivariate logistic regression analysis was used to identify the risk factors for severe COVID-19 in maintenance hemodialysis patients. <b>Results</b> There were statistically significant differences in age, aCCI, total lymphocyte count, C-reactive protein and D-dimer between the two groups (P＜0.01). Multivariate logistic regression analysis showed that older age and higher C-reactive protein level were the independent risk factors for severe COVID-19 in maintenance hemodialysis patients (OR=1.256, 95%CI:1.016-1.553, P=0.035; OR=1.021, 95%CI: 1.001-1.041, P=0.041). <b>Conclusion</b> The COVID-19 vaccination rate of maintenance hemodialysis patients is low, the overall age is older. Older age and higher level of C-reactive protein are independent risk factors for severe COVID-19 in maintenance hemodialysis patients.
Authors and Affiliations
DONG Chunli, SONG Haitao, YU Xin, LI Zhenxiao, WANG Yongjie
Keywords
Related Articles
- EP ID EP735808
- DOI 10.13429/j.cnki.cjcr.2024.01.016
- Views 56
- Downloads 0
Effect of subanesthetic dose of esketamine on perioperative hemodynamics in patients undergoing lumbar surgery under general anesthesia
Objective To analyze the effect of subanesthetic dose of esketamine on perioperative hemodynamics and adverse events in patients undergoing lumbar spine surgery under general anesthesia. Methods The clinical data of 70...
Effects of laparoscopic surgery combined with hyperthermic intraperitoneal chemotherapy on postoperative coagulation indicators in patients with colorectal cancer
Objective To observe the changes of coagulation function in patients with colorectal cancer (CRC) after laparoscopic surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC). Methods Sixty patients with CR...
Advance in immune microenvironment and immunotherapy in triple-negative breast cancer
Breast cancer is the most common malignant tumor in women. Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, characterized by poor differentiation, high rate of progression and poor pr...
lncRNA ANCR regulating the effects of miR-497-5p on vascular lumen formation and apoptosis of gastric cancer cells
<b>Objective</b> To explore the effects of lncRNA ANCR regulating miR-497-5p on vascular lumen formation, apoptosis and PI3K/AKT signaling pathway of gastric cancer cells. <b>Methods</b> Gastric cancer cells were collect...
Special review and analysis on the clinical unreasonable use of proton pump inhibitors for injection
<b>Objective</b> To analyze the irrational use of proton pump inhibitors (PPI) for injection in clinical practice and its reasons, and to improve the rationality of PPI through appropriate intervention measures. <b>Metho...