Risk factors for skin cancer development in patients after organ transplantation
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2012, Vol 66, Issue 0
Abstract
Cancer has become the second most common cause of death in patients after organ transplantation. Among all cancers arising de novo after transplantation skin cancers are the most common, accounting for 95% of all skin neoplasms. Due to the significantly higher morbidity, aggressive, rapid progression of cancer and unfavorable prognosis, the population requires a specific oncological approach. Therefore, special attention should be paid to factors predisposing to the development of cancer, including skin cancer, in patients after organ transplantation. Some of these factors are well understood, while the role of others is still ambiguous. Among the etiological factors mentioned are those that are associated with the recipient. These include genetic factors such as male sex, fair skin and inability to be tanned, and compatibility of the HLA system, and non genetic factors such as patient age, chronic skin ulcers and scars, the type of transplanted organ, immunosuppression, and particularly the type and cumulative doses of drugs. In addition, the pathogenesis of cancer is influenced by environmental factors such as exposure to sunlight and therefore latitude, ionizing radiation, chemical carcinogens and viral infections. Knowledge of etiological factors and mechanisms of etiopathogenesis allow for indication and observation of patients with increased risk of cancer as well as faster healing in these patients.
Authors and Affiliations
Beata Imko-Walczuk, Maria Piesiaków, Aleksandra Okuniewska, Janusz Jaśkiewicz, Sławomir Lizakowski, Alicja Dębska-Ślizień, Bolesław Rutkowski
Keywords
Related Articles
- EP ID EP66806
- DOI -
- Views 148
- Downloads 0
Choroba Alzheimera a produkty degradacji białka APP. Formowanie i różnorodność form fibrylujących peptydów – wybrane aspekty
Peptydowe produkty degradacji białka APP (Amyloid Precursor Protein, APP), to najważniejsze białka w patofizjologii choroby Alzheimera (Alzheimer’s disease, AD). Choć dobrze już poznane, jednak nadal budzą zainteresowani...
Cannabinoids – a new weapon against cancer?
Cannabis has been cultivated by man since Neolithic times. It was used, among others for fiber and rope production, recreational purposes and as an excellent therapeutic agent. The isolation and characterization of the s...
The change of electric potentials in the oral cavity after application of extremely low frequency pulsed magnetic field
Electric potentials occurring in the oral cavity deserve attention as they may cause various diseases and subjective feelings, which are very difficult to treat. The aim of this study was to evaluate the electric potenti...
Substancje pochodzenia roślinnego przeciwdziałające kardiotoksyczności towarzyszącej chemioterapii nowotworów
Prawie wszystkie leki przeciwnowotworowe stosowane klinicznie wykazują właściwości toksyczne w stosunku do mięśnia sercowego. Kardiotoksyczność występująca podczas chemioterapii przeciwnowotworowej może być czynnikiem li...
3-Bromopyruvate as a potential pharmaceutical in the light of experimental data
3-Bromopyruvate (3-BrPA) is an halogenated analogue of pyruvic acid known for over four decades as an alkylating agent reacting with thiol groups of many proteins. It enters animal cells like a lactate: via monocarboxyli...