ROLE LABORATORY MARKERS OF ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH HYPERTENSION IN CONJUNCTION WITH GOUT
Journal Title: World Science - Year 2017, Vol 5, Issue 5
Abstract
The article presents the results of a prevalence of hypertension (HT) among patients with gout and the role of laboratory markers of endothelial dysfunction in this group of patients. We examined 50 male patients with gout. HT was registered in 84% of patients, moreover the gout was preceded by HT in 52% of cases. The increase in the number of patients with chronic gout is due to the increase in the degree of HT. Significantly greater number of affected joints as well as an incidence of subcutaneous tophi and nephrolithiasis have been reported in patients with HT. In addition, these patients have poor adherence to antihypertensive treatment, as only 42% of patients with HT receive treatment. Significantly higher levels of C-reactive protein (CRP), ristocetin-induced platelet aggregation (RIPA), intima-media thickness (IMT) have been reported in patients with HT combined with gout in comparison with patients without gout, reflecting a significant breach of endothelial function. The increase in the number of cardiovascular cases in patients with gout leads to the increase of CRP, RIPA, IMT, it causes doctor’s need to monitor these indicators.
Authors and Affiliations
A. P. Kuzmina, O. M. Lazarenko
Keywords
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