Role of Oxidative Stress in COPD. Can we Use A Novel Biomarker To Measure It?
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 9
Abstract
Chronic Obstructive Pulmonary Disease (COPD) is a common, preventable disease characterized by persistent respiratory symptoms and airway narrowing. It has been predicted by the WHO to become the 3rd leading cause of death by 2030. The chief pathogenesis at play involves an imbalance of oxidants and anti-oxidants, a term called “oxidative stress”. Ischemia Modified Albumin (IMA) is a novel biomarker shown to be elevated in various states of ischemia and oxidative stress. This study was done with the aim of determining the association between IMA and COPD and also its associated factors. A cross sectional study was done on 20 consecutive patients hospitalized with COPD. The control group encompassed 20 apparently healthy volunteers. Serum samples were obtained from both groups and the levels of IMA were determined using the Albumin Cobalt-binding test. In addition, patient information was obtained from records pertaining to various covariates. On analysis, Serum IMA was very significantly reduced in patients with COPD compared to the control group {0.3068 ± 0.09924 vs 0.5908 ± 0.1351} with a p-value of < 0.0001. There was also found to be a positive correlation between the levels of IMA and the degree of smoking thereby reinstating that IMA rises with an increased exposure to smoking.(correlation coefficient r=0.6671, 95% CI:0.2561 to 0.8738, p<0.01). This study thus shows that there is some altered oxidative pattern in patients with COPD. Also, the correlation with smoking makes for a possible marker to measure the levels of oxidative stress. We recommend further large scale studies using more specific methods like ELISA to determine the exact nature of this association.
Authors and Affiliations
Shweta Paulraj, Prashanth Ashok Kumar, Kavitha Subramaniam, Ramaraju Karthikeyan Karthikeyan
Keywords
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- EP ID EP255964
- DOI 10.9790/0853-1609035256
- Views 95
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