Role of Oxidative Stress in COPD. Can we Use A Novel Biomarker To Measure It?
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 9
Abstract
Chronic Obstructive Pulmonary Disease (COPD) is a common, preventable disease characterized by persistent respiratory symptoms and airway narrowing. It has been predicted by the WHO to become the 3rd leading cause of death by 2030. The chief pathogenesis at play involves an imbalance of oxidants and anti-oxidants, a term called “oxidative stress”. Ischemia Modified Albumin (IMA) is a novel biomarker shown to be elevated in various states of ischemia and oxidative stress. This study was done with the aim of determining the association between IMA and COPD and also its associated factors. A cross sectional study was done on 20 consecutive patients hospitalized with COPD. The control group encompassed 20 apparently healthy volunteers. Serum samples were obtained from both groups and the levels of IMA were determined using the Albumin Cobalt-binding test. In addition, patient information was obtained from records pertaining to various covariates. On analysis, Serum IMA was very significantly reduced in patients with COPD compared to the control group {0.3068 ± 0.09924 vs 0.5908 ± 0.1351} with a p-value of < 0.0001. There was also found to be a positive correlation between the levels of IMA and the degree of smoking thereby reinstating that IMA rises with an increased exposure to smoking.(correlation coefficient r=0.6671, 95% CI:0.2561 to 0.8738, p<0.01). This study thus shows that there is some altered oxidative pattern in patients with COPD. Also, the correlation with smoking makes for a possible marker to measure the levels of oxidative stress. We recommend further large scale studies using more specific methods like ELISA to determine the exact nature of this association.
Authors and Affiliations
Shweta Paulraj, Prashanth Ashok Kumar, Kavitha Subramaniam, Ramaraju Karthikeyan Karthikeyan
Keywords
Related Articles
- EP ID EP255964
- DOI 10.9790/0853-1609035256
- Views 60
- Downloads 0
Clinical Profile Of Amblyopia In A Tertiary Health Care Centre In Central India
Introduction: Amblyopia is major cause of blindness in world. It is functional reduction in visual acuity of an eye during critical period of visual development. Most sensitive period for development of amblyopia is from...
Management of Postoperative Wound in Neurosurgery Department of RIMS, A Single Centre Experience
Post operative woundhealing problems in the neurosurgical patient can be particularly bothersome, owing to various specific risk factors involved. These may vary from simple wound dehiscence to complex multilayer defects...
Kimura’s Disease - a Rare Chronic Inflammatory Entity
Kimuras disease is a rare chronic inflammatory disease maily involves the soft tissue of the head and neck region and lymph nodes. Clinical differential diagnoses of KD include lymphoma, lymphangioma, reactive lymphadeno...
A Comparative Study of Different Surgical Techniques in Common Bile Duct Exploration under Protocols of Enhanced Recovery after Surgery
Background:Common bile duct exploration (CBDE), a relatively common procedure for common bile duct patients, includes various techniques of surgical treatment. Enhanced Recovery after Surgery (ERAS) incorporates a number...
A Cross Sectional Study to Assess the Prevalence of Vitamin B 12 Deficiency Among Type 2 Diabetes Mellitus Patients on Metformin Therapy in A Tertiary Care Hospital in Eastern India.
Introduction: Vitamin B12, a water soluble vitamin plays a pivotal role in DNA synthesis, Haemopoesis and maintenance of functional integrity of nervous system. A known pharmacological cause of Vitamin B12 deficiency is...