RP-HPLC method development and validation for simultaneous estimation of Amlodipine besylate and Telmisartan in tablet dosage form
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2017, Vol 5, Issue 1
Abstract
RP-HPLC method was developed and validated as per ICH guidelines for the estimation of Amlodipine and Telmisartan. Simultaneous Estimation of Amlodipine and Telmisartan were carried out by RP- HPLC using Phosphate buffer (PH 4.0): Acetonitrile (42:58) and column Phenomenex Luna C-18 (250*4.6 mm, 5um) as a stationary phase and peak was observed at 236 nm which was selected as a wavelength for quantitative estimation. After the development of the method, it was validated for specificity, linearity, precision, accuracy, robustness and ruggedness studies. The parameters were within the limits. The method was found to be suitable for the estimation of amlodipine besylate and temisartan in tablet dosage form.
Authors and Affiliations
Shaik Maimoon, K. Narendra Kumar Reddy, P. Swetha
Keywords
Related Articles
- EP ID EP33424
- DOI -
- Views 302
- Downloads 0
Association of 22q11.2 deletion in children with congenital heart defects from Andhra Pradesh, India
DiGeorge syndrome is a genetic disorder associated with chromosome 22q11.2 deletion and manifests with variable clinical findings. Most of the cases occur sporadically although vertical transmission has been documented...
A review on biotransformation
Biotransformation means chemical alteration of chemicals such as nutrients, amino acids, toxins, and drugs in the body. It is also needed to render nonpolar compounds polar so that they are not reabsorbed in renal tubu...
Novel drug delivery of Minocycline aganist bacteria by using a polymer citric acid macro molecule
The main objective of the study is to synthesis 3rd generation of citric acid dendrimer and by attaching polyethylene glycol for reducing non specific systemic toxicity, increases the circulation time of the drug and s...
Formulation development and evaluation of matrix tablets of propranolol HCl by using release retarding agents
The main aim of the present work is to formulate and develop matrix tablets of Propranolol HCl. Selected suitable method for preparation process of Direct compression method for matrix tablets of Propranolol HCl by usi...
RECENT TRENDS IN SCOPE AND OPPORTUNITY OF CLINICAL RESEARCH IN INDIA
Clinical Research is one of the most knowledge-intensive industry. It is complete biography of drug from its inception in the lab to its introduction to the consumer market and beyond. Any molecule is identified is sub...