RP-HPLC method development and validation for simultaneous estimation of Amlodipine besylate and Telmisartan in tablet dosage form
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2017, Vol 5, Issue 1
Abstract
RP-HPLC method was developed and validated as per ICH guidelines for the estimation of Amlodipine and Telmisartan. Simultaneous Estimation of Amlodipine and Telmisartan were carried out by RP- HPLC using Phosphate buffer (PH 4.0): Acetonitrile (42:58) and column Phenomenex Luna C-18 (250*4.6 mm, 5um) as a stationary phase and peak was observed at 236 nm which was selected as a wavelength for quantitative estimation. After the development of the method, it was validated for specificity, linearity, precision, accuracy, robustness and ruggedness studies. The parameters were within the limits. The method was found to be suitable for the estimation of amlodipine besylate and temisartan in tablet dosage form.
Authors and Affiliations
Shaik Maimoon, K. Narendra Kumar Reddy, P. Swetha
Keywords
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