SALIVARY NITRIC OXIDE (NO¬2+NO3) AS BIOMARKER OF DENTAL CARIES IN ADULTS: AN INVIVO STUDY
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 11
Abstract
The purpose of the study was to evaluate salivary nitric oxide (NO¬2+NO3) as a biomarker of dental caries in adults and to determine the correlation between salivary nitric oxide levels and DMFT index. Eighty healthy adults were divided into two groups: as caries free consisting of 20 individuals and caries active group consisting of 60 individuals. The caries active group was further divided into three subgroups based on the DMFT score (D=decayed, M=missing, F=filled, T=teeth) as follows: Group I (DMFT<3), Group II (DMFT<10) and Group III (DMFT>10), each group consisting of 20 individuals. Saliva collected was estimated for nitric oxide (NO¬2+NO3) level by Griess reaction method. One-way ANOVA was used to correlate between concentration of nitric oxide (NO¬2+NO3) in saliva and DMFT index in caries free and caries active groups. Results are presented as mean + standard deviation value. The mean level of nitric oxide in saliva of control group was 49.91±15.90 and that of group I, II and III were 32.10±5.91, 32.09±7.61 and 30.14±3.06 respectively. The mean level of nitric oxide (NO¬2+NO3) was higher in caries free group when compared to caries active group and was statistically significant and suggests that increased NO production might contribute to lower caries incidence in adults.
Authors and Affiliations
Mithra Hegde , Nidarsh Hegde , Aparna Ashok , Shilpa Shetty
Keywords
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